# Complications of Central Venous Line Insertion: A Case Series

**Authors:** Saurav Shrestha, Rehan Pradhan, Nikol Guragain

PMC · DOI: 10.31729/jnma.v64i293.9282 · JNMA: Journal of the Nepal Medical Association · 2026-01-31

## TL;DR

This paper presents four rare but serious complications from central venous catheter insertion, emphasizing the need for careful procedures and imaging.

## Contribution

The paper adds to clinical knowledge by documenting uncommon complications and reinforcing procedural best practices.

## Key findings

- A right internal mammary artery aneurysm occurred due to CVC malplacement.
- A retained guidewire in the inferior vena cava was discovered after a year and surgically removed.
- Use of real-time imaging and post-insertion confirmation can reduce complications and improve outcomes.

## Abstract

Central venous catheter (CVC) insertion is a commonly performed procedure in critically ill patients. While generally safe, it carries risks of potentially serious complications, particularly when performed without ultrasound guidance or in emergent settings. We report a series of four patients who developed uncommon but significant complications following CVC placement. The first case describes the right internal mammary artery aneurysm after malplacement of CVC line. The second case outlines the formation of sternocleidomastoid hematoma after internal jugular vein access. The third case involved a guidewire retained in the inferior venacava for over one year, discovered incidentally on imaging and removed surgically. The fourth case developed a subclavian artery pseudoaneurysm post-CVC insertion, confirmed on CT angiography and surgically managed. These cases highlights the importance of strict procedural protocols, operator awareness, use of real-time imaging, and post-insertion confirmation imaging to minimize CVC-related complications. Early identification and appropriate management can significantly reduce morbidity.

## Full-text entities

- **Genes:** F2 (coagulation factor II, thrombin) [NCBI Gene 2147] {aka PT, RPRGL2, THPH1}
- **Diseases:** vomiting (MESH:D014839), arterial trauma (MESH:D020212), acute kidney injury (MESH:D058186), cardiac conduction abnormalities (MESH:D006327), fatigue (MESH:D005221), COPD (MESH:D029424), bleeding (MESH:D006470), cardiac arrhythmias (MESH:D001145), Chronic Kidney Disease (MESH:D051436), swelling (MESH:D004487), neck swelling (MESH:D006258), Subclavian artery pseudoaneurysm (MESH:D017541), aneurysm of the (MESH:D000783), shortness of breath (MESH:D004417), compressive (MESH:D009408), hemothorax (MESH:D006491), epigastric pain (MESH:D010146), hyperkalemia (MESH:D006947), hematoma (MESH:D006406), complication (MESH:D008107), bloodstream infections (MESH:D018805), AV fistula (MESH:D001164), flapping tremors (MESH:D000070600), tubercular (MESH:D014390), embolism (MESH:D004617), cough (MESH:D003371), Vascular injury (MESH:D057772), pneumothorax (MESH:D011030), air embolism (MESH:D004618), End Stage Kidney Disease (MESH:D007676), artery (MESH:D012078), infective (MESH:D007239), hemopneumothorax (MESH:D006468), uremic symptoms (MESH:D006463), agitation (MESH:D011595), Pulmonary Tuberculosis (MESH:D014397), tremors (MESH:D014202), hypertensive (MESH:D006973), thrombosis (MESH:D013927), internal mammary artery aneurysm (MESH:D002340)
- **Chemicals:** oxygen (MESH:D010100)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12925836/full.md

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12925836/full.md

## References

11 references — full list in the complete paper: https://tomesphere.com/paper/PMC12925836/full.md

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Source: https://tomesphere.com/paper/PMC12925836