# Massive hemothorax following CT-guided lung biopsy: A rare iatrogenic complication managed conservatively

**Authors:** Bahman Rasuli, Ali Forat Yazdi

PMC · DOI: 10.1016/j.tcr.2026.101303 · 2026-02-12

## TL;DR

A rare case of massive hemothorax after a lung biopsy was successfully treated without surgery in a stable patient.

## Contribution

Demonstrates successful conservative management of a life-threatening complication following a lung biopsy.

## Key findings

- A 35-year-old woman developed a massive hemothorax after a CT-guided lung biopsy.
- Conservative management led to complete recovery without surgical intervention.
- Trauma-based principles were effective in managing the complication.

## Abstract

CT-guided transthoracic lung biopsy is an essential diagnostic technique for evaluating pulmonary lesions. Although rare, major complications such as hemothorax can be life-threatening. We report the case of a 35-year-old woman who developed a rapidly enlarging right hemothorax several hours after CT-guided core needle biopsy of a pleura-abutting right lower lobe mass. There was no arterial extravasation, and chest tube drainage yielded approximately 1500 mL of dark, clotted blood, suggesting a venous or tumoral source. The patient remained hemodynamically stable and achieved complete recovery with conservative management. This case highlights that even massive post-biopsy hemothorax can be successfully treated non-operatively in stable patients by adhering to trauma-based management principles.

## Full-text entities

- **Genes:** TTF1 (transcription termination factor 1) [NCBI Gene 7270] {aka TTF-1, TTF-I}, NAPSA (napsin A aspartic peptidase) [NCBI Gene 9476] {aka KAP, Kdap, NAP1, NAPA, NR1H2-AS1, SNAPA}
- **Diseases:** atelectasis (MESH:D001261), cough (MESH:D003371), arterial injury (MESH:D057772), pneumothorax (MESH:D011030), coagulopathies (MESH:D001778), venous or (MESH:D014647), vascular malformations (MESH:D054079), chest pain (MESH:D002637), bleeding (MESH:D006470), pleural effusion (MESH:D010996), respiratory distress (MESH:D012128), Hemothorax (MESH:D006491), trauma (MESH:D014947), neoplasms (MESH:D009369), adenocarcinoma (MESH:D000230), lung mass (MESH:D008171), dyspnea (MESH:D004417)
- **Chemicals:** oxygen (MESH:D010100)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12925473/full.md

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Source: https://tomesphere.com/paper/PMC12925473