# Neurosarcoidosis Presenting With Cerebellar Hemorrhage and Spinal Cord Involvement: A Case Report

**Authors:** Seyed Mostafa Razavi, Emily Storm, Karan K Topiwala

PMC · DOI: 10.7759/cureus.102118 · 2026-01-22

## TL;DR

A 37-year-old man with sarcoidosis developed neurological symptoms and cerebellar hemorrhage, highlighting the rare and serious CNS complications of neurosarcoidosis.

## Contribution

The case reports a rare cerebellar hemorrhage associated with neurosarcoidosis and emphasizes its underrecognized cerebrovascular involvement.

## Key findings

- MRI showed rare cerebellar hemorrhage with edema and spinal cord lesions in a neurosarcoidosis patient.
- CSF and biopsy confirmed neurosarcoidosis, and immunosuppressive therapy improved neurological deficits.
- The case underscores the need for early diagnosis to prevent severe neurological outcomes.

## Abstract

Neurosarcoidosis is a rare manifestation of sarcoidosis, a systemic granulomatous disease. It presents a diagnostic challenge due to its varied clinical and radiologic features.

We describe a 37-year-old male with biopsy-proven pulmonary sarcoidosis who developed progressive neurological symptoms, including dizziness, imbalance, diplopia, and lower extremity weakness. MRI revealed diffuse leptomeningeal enhancement, cervical spinal cord lesions, and left cerebellar hemorrhage with surrounding vasogenic edema, a relatively rare finding in neurosarcoidosis. Cerebrospinal fluid (CSF) analysis showed inflammatory changes, and mediastinal lymph node biopsy confirmed non-necrotizing granulomas. The patient was treated with high-dose corticosteroids followed by immunosuppressive therapy, leading to gradual improvement in gait and strength.

This case highlights the importance of recognizing neurosarcoidosis as a potential cause of central nervous system hemorrhage. Cerebrovascular involvement, particularly intracerebral hemorrhage, is underrecognized but can have serious consequences, making early diagnosis and aggressive immunosuppressive therapy critical in preventing long-term neurological deficits.

## Linked entities

- **Diseases:** sarcoidosis (MONDO:0008399), neurosarcoidosis (MONDO:0045047)

## Full-text entities

- **Genes:** TNF (tumor necrosis factor) [NCBI Gene 7124] {aka DIF, IMD127, TNF-alpha, TNFA, TNFSF2, TNLG1F}
- **Diseases:** NS (MESH:C535814), infarcts (MESH:D007238), Cerebellar Hemorrhage (MESH:D020201), granuloma (MESH:D006099), multiple sclerosis (MESH:D009103), fungal (MESH:D009181), gait instability (MESH:D043171), lower extremity weakness (MESH:D020335), infectious meningitis (MESH:D003141), hypertension (MESH:D006973), neurological damage (MESH:D020196), demyelinating disease (MESH:D003711), diplopia (MESH:D004172), intracerebral hemorrhage (MESH:D002543), urinary retention (MESH:D016055), coagulopathy (MESH:D001778), Sarcoidosis (MESH:D012507), ischemic stroke (MESH:D002544), cough (MESH:D003371), vascular injury (MESH:D057772), Cerebrovascular involvement (MESH:D002561), involvement (MESH:C564676), lymphocytic pleocytosis (MESH:D007964), imbalance (MESH:D000137), dizziness (MESH:D004244), intracranial hemorrhage (MESH:D020300), lymphadenopathy (MESH:D008206), vasogenic edema (MESH:D001929), granulomatous disease (MESH:D006105), autoimmune diseases (MESH:D001327), nausea (MESH:D009325), obesity (MESH:D009765), Hemorrhagic (MESH:D006470), fatigue (MESH:D005221), leptomeningeal disease (MESH:D008577), vascular malformations (MESH:D054079), stroke (MESH:D020521), Spinal lesion (MESH:D013122), neurological deficits (MESH:D009461), Cord (MESH:D013118), cranial neuropathies (MESH:D003389), vomiting (MESH:D014839), pulmonary sarcoidosis (MESH:D017565), systemic disease (MESH:D034721), vasculitis (MESH:D014657), gastroesophageal reflux disease (MESH:D005764), granulomatous inflammation (MESH:D007249), primary vasculitis (MESH:D020293), hypertensive hemorrhage (MESH:D020299), granulomatous vasculitis (MESH:D015267), blurry vision (MESH:D014786), balance disturbances (MESH:D014832), impaired balance (MESH:D060825), tinnitus (MESH:D014012), pulmonary (MESH:D008171), neurological involvement (MESH:C538190), neoplasms (MESH:D009369), CNS hemorrhage (MESH:D002493)
- **Chemicals:** Prednisone (MESH:D011241), steroid (MESH:D013256), glucose (MESH:D005947), AFB (-), methylprednisolone (MESH:D008775), methotrexate (MESH:D008727), infliximab (MESH:D000069285), carbon (MESH:D002244)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12924887/full.md

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Source: https://tomesphere.com/paper/PMC12924887