Discovery of spectosis supports the key role of caspase-8 in determining the type of cell death in mature erythrocytes and erythrocyte death-driven immunogenicity

Anton Tkachenko

PMC · DOI:10.1038/s41420-026-02989-0·February 21, 2026

Discovery of spectosis supports the key role of caspase-8 in determining the type of cell death in mature erythrocytes and erythrocyte death-driven immunogenicity

Anton Tkachenko

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Abstract

Linked entities

Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.

Genes12

CASP3 MLKL RIPK3 GSDMD IL18 CASP8 RIPK1 NLRP3 CASP1 FAS PYCARD IL1B

Proteins12

Species1

Homo sapiens(human · species)

Chemicals3

Ca2+heme PS

Diseases2

necrotic inflammation

Figures1

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Taxonomy

TopicsErythrocyte Function and Pathophysiology · Cell death mechanisms and regulation · Phagocytosis and Immune Regulation