# Mushrooms: The Good, the Bad, and the Deadly

**Authors:** Harikrishna Choudary Ponnam, Ragini Gopagoni, Saketh Parsi, Laxmi Sakamuri, Keyvan Ravakhah

PMC · DOI: 10.7759/cureus.102089 · 2026-01-22

## TL;DR

This paper discusses the dangers of poisonous mushrooms like Amanita phalloides and highlights the importance of early detection and prevention.

## Contribution

The paper presents two clinical cases of severe Amanita poisoning to emphasize diagnostic and management challenges.

## Key findings

- Amanita phalloides poisoning leads to significant morbidity and mortality due to amatoxins.
- Delayed diagnosis complicates treatment and worsens outcomes in mushroom poisoning cases.
- Public health strategies including education and prevention are critical to reducing mushroom-related risks.

## Abstract

Mushrooms are widely consumed for their culinary and nutritional value; however, some species pose serious toxicological risks. While edible varieties such as Agaricus bisporus dominate global and US markets, others, including Amanita phalloides, contain potent amatoxins associated with high morbidity and mortality. Mushroom poisoning, or mycetism, occurs across diverse populations and commonly results from accidental ingestion or species misidentification. Diagnosis is often delayed due to difficulties in accurate identification, complicating timely management. This report aims to describe two cases of severe Amanita poisoning to illustrate the clinical presentation, diagnostic challenges, and management strategies, including supportive care, antidotal therapy, and consideration for liver transplantation. It also aims to highlight the public health impact of amatoxin-containing mushrooms and underscore the need for early recognition, culturally sensitive education, and effective preventive measures to reduce mushroom-related health risks.

## Linked entities

- **Species:** Agaricus bisporus (taxon 5341), Amanita phalloides (taxon 67723)

## Full-text entities

- **Diseases:** gastrointestinal symptoms (MESH:D012817), poisoning (MESH:D011041), hepatocellular necrosis (MESH:D047508), abdominal pain (MESH:D015746), nausea (MESH:D009325), diarrhea (MESH:D003967), Mushroom poisoning (MESH:D009145), hypotension (MESH:D007022), vomiting (MESH:D014839), coagulopathy (MESH:D001778), metabolic acidosis (MESH:D000138), acute liver failure (MESH:D017114), toxicity (MESH:D064420), hepatic failure (MESH:D017093), hepatocellular injury (MESH:D056486), DIC (MESH:D004211)
- **Chemicals:** phalloidin (MESH:D010590), phallacidin (MESH:C017613), Benzyl penicillin (MESH:D010400), Amanita poisoning (-), Amatoxin (MESH:C018207), monosodium glutamate (MESH:D012970), bicarbonate (MESH:D001639), phallotoxins (MESH:C018358)
- **Species:** Amanita virosa (European destroying angel, species) [taxon 78357], Agaricus bisporus (common mushroom, species) [taxon 5341], Human immunodeficiency virus 1 (no rank) [taxon 11676], Amanita bisporigera (eastern North American destroying angel, species) [taxon 87325], Homo sapiens (human, species) [taxon 9606], Amanita phalloides (death cap, species) [taxon 67723]

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12924708/full.md

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Source: https://tomesphere.com/paper/PMC12924708