# Neonatal Purpura Fulminans: An Unusual Cause of Leukocoria, Retinal Detachment, and Vitreous Hemorrhage in Neonates

## TL;DR

Neonatal purpura fulminans is a rare blood clotting disorder that can cause severe eye problems like retinal detachment and vitreous hemorrhage in newborns.

## Contribution

This paper presents a case where ocular symptoms appeared before other signs of the disease.

## Key findings

- The case showed multiple purpuric skin lesions along with severe eye complications.
- Leukocoria was observed before other typical symptoms of the condition.
- The patient had total retinal detachment and vitreous hemorrhage.

## Abstract

Neonatal purpura fulminans is a rare but life-threatening thrombotic disorder caused by congenital deficiencies of protein C. It presents with hemorrhagic necrosis of the skin due to the underlying dysfunction of coagulation. Ocular findings include leukocoria, chemosis, periorbital edema, posterior synechia, vitreous hemorrhage, retinal detachment, and retinal dysplasia. Sometimes, leukocoria may occur before any other manifestations. Here, we describe a case of neonatal purpura fulminans characterized by multiple purpuric skin lesions, leukocoria, vitreous hemorrhage, and total retinal detachment.