# A Modern Approach to Brown-Séquard Syndrome: A Case Report

**Authors:** Lisle W Blackbourn, Sarah Khan, Jayishnu Srinivas, Johan Sosa De La Cruz, Swetha Vennavaram

PMC · DOI: 10.7759/cureus.102036 · 2026-01-21

## TL;DR

This case report describes an 82-year-old man with symptoms consistent with Brown-Séquard syndrome and explores its diagnosis and treatment options.

## Contribution

The paper provides a modern diagnostic and treatment approach for Brown-Séquard syndrome through a detailed case study.

## Key findings

- The patient exhibited classic Brown-Séquard syndrome symptoms including unilateral motor weakness and sensory deficits.
- The case emphasizes the importance of tailored investigations for accurate differential diagnosis of BSS.
- Modern diagnostic workup is highlighted for managing BSS and its differentials.

## Abstract

In this case, we discuss an 82-year-old male patient with a combination of motor weakness and loss of proprioception on one side of the body, together with reduced pain and temperature sensation on the opposite side, which is characteristic of Brown-Séquard syndrome (BSS). This case highlights the differential diagnoses of those presenting with BSS as well as the diagnostic workup in the modern day for BSS. This case gives the reader the opportunity to go through tailored investigations and treatment for the various BBS differentials.

## Linked entities

- **Diseases:** Brown-Séquard syndrome (MONDO:0008853)

## Full-text entities

- **Genes:** KRT20 (keratin 20) [NCBI Gene 54474] {aka CD20, CK-20, CK20, K20, KRT21}, NEFL (neurofilament light chain) [NCBI Gene 4747] {aka CMT1F, CMT2E, CMTDIG, NF-L, NF68, NFL}, IL6R (interleukin 6 receptor) [NCBI Gene 3570] {aka CD126, HIES5, IL-1Ra, IL-6R, IL-6R-1, IL-6RA}, MOG (myelin oligodendrocyte glycoprotein) [NCBI Gene 4340] {aka BTN6, BTNL11, MOGIG2, NRCLP7}, AQP4 (aquaporin 4) [NCBI Gene 361] {aka MIWC, MLC4, WCH4, hAQP4}
- **Diseases:** systemic cancer (MESH:D009369), loss of proprioception (MESH:D020886), motor weakness (MESH:D018908), abdominal burning pain (MESH:D015746), spinal stenosis (MESH:D013130), degenerative spondylosis (MESH:D055009), hematomas (MESH:D006406), Inflammatory (MESH:D007249), penetrating (MESH:D015807), injury (MESH:D014947), compressive lesions (MESH:D009408), pain (MESH:D010146), fractures (MESH:D050723), autoimmune myelopathies (MESH:D013118), paraplegia (MESH:D010264), spinal cord injury (MESH:D013119), spinal cord compression (MESH:D013117), neurological deficits (MESH:D009461), ependymomas (MESH:D004806), disc herniation (MESH:D007405), hemorrhage (MESH:D006470), BBS (MESH:D049932), anterior spinal artery syndrome (MESH:D020759), autoimmune (MESH:D001327), loss of pain and temperature (MESH:C565868), stroke (MESH:D020521), dysarthria (MESH:D004401), fatigue (MESH:D005221), sarcoidosis (MESH:D012507), artery (MESH:D012078), aphasia (MESH:D001037), pleocytosis (MESH:D007964), weight loss (MESH:D015431), intramedullary lesions (MESH:D013120), atherosclerosis (MESH:D050197), demyelinating process (MESH:D003711), hypertension (MESH:D006973), intracranial abnormalities (MESH:D001927), meningiomas (MESH:D008579), NMOSD (MESH:D009471), MS (MESH:D009103), dislocations (MESH:D004204), infectious (MESH:D003141), lower extremity weakness (MESH:D020335), astrocytomas (MESH:D001254), axonal damage (MESH:D001480), cognitive deficits (MESH:D003072), BSS (MESH:D018437), chronic back pain (MESH:D059350), spinal cord infarction (MESH:D007238), sensory loss (MESH:C580162)
- **Chemicals:** tocilizumab (MESH:C502936), copper (MESH:D003300), methylprednisolone (MESH:D008775), rituximab (MESH:D000069283), thiamine (MESH:D013831), PLEX (-), riluzole (MESH:D019782), folate (MESH:D005492), vitamin B12 (MESH:D014805), minocycline (MESH:D008911)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12923986/full.md

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Source: https://tomesphere.com/paper/PMC12923986