# Polypharmacology of anthelmintics at host and parasite ion channels

**Authors:** John D. Chan, Spencer S. Ericksen, Mostafa Zamanian

PMC · DOI: 10.1371/journal.ppat.1013977 · PLOS Pathogens · 2026-02-20

## Full-text entities

- **Genes:** TRPM5 (transient receptor potential cation channel subfamily M member 5) [NCBI Gene 29850] {aka LTRPC5, MTR1}, CA5B (carbonic anhydrase 5B) [NCBI Gene 11238] {aka CA-VB, CAVB}, glc-1 (Glutamate-gated chloride channel alpha) [NCBI Gene 180086], COL9A2 (collagen type IX alpha 2 chain) [NCBI Gene 1298] {aka DJ39G22.4, EDM2, MED, STL5}, WARS1 (tryptophanyl-tRNA synthetase 1) [NCBI Gene 7453] {aka GAMMA-2, HMN9, HMND9, IFI53, IFP53, NEDMSBA}, CA5A (carbonic anhydrase 5A) [NCBI Gene 763] {aka CA5, CA5AD, CAV, CAVA, GS1-21A4.1}
- **Diseases:** Schistosomiasis (MESH:D012552), VSLD (MESH:C537419), paralysis (MESH:D010243), epilepsy drug (MESH:D000069279), infection (MESH:D007239), schistosomal (MESH:D020818), psychotic drug (MESH:D011605)
- **Chemicals:** nitrogens (MESH:D009584), phosphatidylinositol 4,5-bisphosphate (MESH:D019269), histamine (MESH:D006632), Ivermectin (MESH:D007559), glutamate (MESH:D018698), Praziquantel (MESH:D011223), chloride (MESH:D002712), phospholipid (MESH:D010743), Quaaludes (MESH:D008702), arachidonic acid (MESH:D016718), testosterone (MESH:D013739), phenytoin (MESH:D010672), meclonazepam (MESH:C020602), miltefosine (MESH:C039128), fatty acids (MESH:D005227), BZQ (-), barbiturate (MESH:C032232), Benzodiazepines (MESH:D001569), Diethylcarbamazine (MESH:D004049), FPL-64176 (MESH:C071658), Barbiturates (MESH:D001463), phenothiazine (MESH:C031637), 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphoserine (MESH:C050294), Lipids (MESH:D008055), quinazoline (MESH:D011799), pregnenolone sulfate (MESH:C018370), piperazine (MESH:D000077489)
- **Species:** Caenorhabditis elegans (species) [taxon 6239], Platyhelminthes (flatworm, phylum) [taxon 6157], Mus musculus (house mouse, species) [taxon 10090], Brugia malayi (agent of lymphatic filariasis, species) [taxon 6279], C. elegans [taxon 328850], Schistosoma mansoni (species) [taxon 6183], Homo sapiens (human, species) [taxon 9606], Fasciola hepatica (liver fluke, species) [taxon 6192], Drosophila melanogaster (fruit fly, species) [taxon 7227]

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## References

49 references — full list in the complete paper: https://tomesphere.com/paper/PMC12923046/full.md

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Source: https://tomesphere.com/paper/PMC12923046