# Joint modeling of alcohol and tobacco use among adults in Uganda

**Authors:** Grace Kakaire, Edna Chepkemoi Chumoh, Dev Sunuwar, Dev Sunuwar, Dev Sunuwar

PMC · DOI: 10.1371/journal.pone.0327941 · PLOS One · 2026-02-20

## TL;DR

This study explores how alcohol and tobacco use are linked in Uganda, finding shared and unique factors that influence both.

## Contribution

The study introduces a joint modeling approach to analyze alcohol and tobacco use together in a Ugandan context.

## Key findings

- The joint model better fits the data than separate models, indicating shared determinants for alcohol and tobacco use.
- Older age and marital status are linked to higher odds of substance use, while education and being female are protective factors.
- Smoking shows stronger regional and demographic variations compared to alcohol use.

## Abstract

Alcohol and tobacco use are leading modifiable risk factors for non-communicable diseases (NCDs) worldwide. In sub-Saharan Africa, including Uganda, these behaviors are increasingly common but often analyzed separately, limiting understanding of their shared determinants. This study used nationally representative data from the 2014 Uganda WHO STEPS survey to examine individual and joint predictors of current alcohol and tobacco use among adults aged 18–69. Using separate and joint logistic regression models, we assessed associations with demographic, socioeconomic, and health-related factors, applying a shared random effect in the joint model to account for within-individual correlation. The joint model provided better fit (AIC = 6850.13) than the combined separate models (AIC = 6890.73), suggesting a shared latent structure influences both outcomes. Female sex and higher educational attainment were consistently associated with lower odds of substance use, while older age and being separated, divorced, or widowed were linked to higher odds. Smoking-specific interactions showed stronger effects in older and underweight individuals and regional differences were more pronounced for smoking than alcohol. These findings highlight the presence of shared and distinct determinants underlying alcohol and tobacco use in Uganda. While the results suggest potential value in considering these behaviors jointly, further research is needed to evaluate whether integrated intervention strategies are effective in reducing co-occurring substance use.

## Full-text entities

- **Diseases:** Underweight (MESH:D013851), Obese (MESH:D009765), smoking (MESH:D015208), adiposity (MESH:D018205), NCD (MESH:D000073296), overweight (MESH:D050177), Central Obesity (MESH:D056128), malaria (MESH:D008288), HIV/AIDS (MESH:D015658), communicable diseases (MESH:D003141), Disease (MESH:D004194), deaths (MESH:D003643), Hypertension (MESH:D006973), weight loss (MESH:D015431)
- **Chemicals:** Alcohol (MESH:D000438), PONE-D-25-34089R1 (-), nicotine (MESH:D009538)
- **Species:** Nicotiana tabacum (American tobacco, species) [taxon 4097], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12922990/full.md

## References

32 references — full list in the complete paper: https://tomesphere.com/paper/PMC12922990/full.md

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Source: https://tomesphere.com/paper/PMC12922990