# Two pathogens, one disease: Rethinking leprosy diversification through ancient and modern genomes

**Authors:** Maria Lopopolo, Charlotte Avanzi, Nicolás Rascovan

PMC · DOI: 10.1002/ctm2.70631 · Clinical and Translational Medicine · 2026-02-20

## Full-text entities

- **Genes:** RNASEH1 (ribonuclease H1) [NCBI Gene 246243] {aka H1RNA, PEOB2, RNH1}, RAD51 (RAD51 recombinase) [NCBI Gene 5888] {aka BRCC5, FANCR, HRAD51, HsRad51, HsT16930, MRMV2}
- **Diseases:** infectious diseases (MESH:D003141), M. lepromatosis (MESH:C566367), infections (MESH:D007239), Hansen disease (MESH:D007918)
- **Species:** Mycobacterium leprae (species) [taxon 1769], Homo sapiens (human, species) [taxon 9606], Mycobacterium lepromatosis (species) [taxon 480418], Sciurus vulgaris (Eurasian red squirrel, species) [taxon 55149]
- **Cell lines:** NHDP-LPM-9 — Homo sapiens (Human), Induced pluripotent stem cell (CVCL_RG56)

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## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC12922782/full.md

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Source: https://tomesphere.com/paper/PMC12922782