# Treatment Algorithms for Inflammatory Myopathies in Adults: from Guidelines to Clinical Practice

## TL;DR

This paper reviews treatment guidelines for inflammatory myopathies and combines them with clinical experience to guide real-world treatment decisions.

## Contribution

The paper offers a pragmatic, consensus-based approach to managing inflammatory myopathies by integrating guidelines and recent evidence.

## Key findings

- Existing treatment guidelines for inflammatory myopathies show significant heterogeneity.
- Combining guidelines with clinical experience helps address management challenges in real-world settings.
- Recent studies on novel therapies may influence future treatment strategies.

## Abstract

Inflammatory myopathies are a heterogeneous group of systemic autoimmune disorders with highly variable clinical presentations. The limited number of clinical trials has hindered the development of strong evidence-based management strategies. Therefore, there is a pressing need for consensus-driven treatment guidelines tailored to the various clinical and immunological phenotypes. This review combines existing published guidelines with the authors’ clinical experience to provide a comprehensive, pragmatic approach to management.

A comparative review of existing treatment guidelines was recently published, revealing significant heterogeneity in therapeutic approaches and recommendations. This observation is consistent with our own experience during a multidisciplinary meeting, primarily involving internal medicine specialists and rheumatologists. Furthermore, recent clinical trials and observational studies investigating novel therapies offer promising prospects that could influence future clinical decision-making.

Although establishing a unified therapeutic algorithm remains challenging, this review aims to translate current knowledge into clinical practice by integrating existing guidelines, our own clinical experience, and the most recent evidence published on the topic.