# Mechanisms at the Intersection of lncRNA and m6A Biology

## TL;DR

This review explores how the RNA modification m6A affects long noncoding RNAs and their roles in regulating biological processes.

## Contribution

The paper synthesizes current knowledge on the interplay between lncRNAs and m6A, highlighting new mechanistic insights.

## Key findings

- m6A modification influences lncRNA function through writers, erasers, and readers.
- Nuclear lncRNAs regulate chromatin and are modulated by m6A.
- Liquid–liquid phase separation is emerging as a key mechanism in lncRNA and m6A biology.

## Abstract

This review provides a thorough survey of long noncoding RNAs that bear the RNA modification N6-methyladenosine (m6A) and current work to understand the resulting mechanistic and biological consequences. We give an overview of lncRNA and m6A biology first, describing the writers, erasers, and readers of m6A and their targeting of lncRNAs. Next, we give an in-depth review of the field of nuclear lncRNAs that regulate chromatin and their regulation via m6A. We then describe the growing appreciation of liquid–liquid phase separation properties in lncRNA and m6A biology. Finally, we cover examples of cytoplasmic lncRNAs regulated by m6A. Overall, this review aims to emphasize how epitranscriptomics influences noncoding RNA mechanisms to provide additional layers of regulation, integrated into downstream biological processes.