# Fibrolipoma of the Buccal Space in a 47-Year-Old Male: A Case Report

**Authors:** Athanasios Vlachodimitropoulos, Spyridon Lygeros, Michail Athanasopoulos, Dimitra Koumoundourou, Georgios Batsaouras

PMC · DOI: 10.3390/reports9010034 · Reports - Clinical Practice and Surgical Cases · 2026-01-24

## TL;DR

A 47-year-old man had a rare fibrolipoma in his cheek, successfully removed through surgery with a good outcome.

## Contribution

This case report adds to the limited literature on fibrolipomas in the buccal space and emphasizes their surgical management.

## Key findings

- Fibrolipoma was diagnosed histopathologically after imaging suggested a lipoma in the buccal fat pad.
- Complete surgical excision via an intraoral approach provided a curative and cosmetically favorable outcome.
- The case underscores the importance of histopathology for definitive diagnosis despite imaging clues.

## Abstract

Background and Clinical Significance: Fibrolipoma is an uncommon histological variant of lipoma characterized by mature adipose tissue with a significant fibrous component. Intraoral lipomas are rare (only about 1–4% of all lipomas) and lipomas arising in the buccal fat pad (buccal space) are particularly uncommon. Case Presentation: A 47-year-old male presented with a painless, slowly enlarging swelling in the left cheek region. Physical examination revealed a soft, non-tender mass in the buccal space, causing mild bulging of the cheek. Contrast-enhanced computed tomography and magnetic resonance imaging demonstrated a well-circumscribed lesion within the left buccal fat pad suggestive of a lipoma. The tumor was excised entirely via an intraoral approach under general anesthesia. Histopathological examination showed lobules of mature adipocytes interspersed with dense fibrous connective septa consistent with a diagnosis of a fibrolipoma. The postoperative course was uneventful. Conclusions: This case highlights that fibrolipoma, while rare in the maxillofacial region, should be included in the differential diagnosis of buccal space tumors. Imaging studies can aid in identifying the fatty nature and extent of such lesions, but definitive diagnosis relies on histopathology. The buccal fat pad’s anatomy allows an intraoral surgical approach in appropriate cases, providing direct access and excellent cosmetic outcomes. Complete excision is curative in benign fibrolipomas, and careful surgical technique prevents injury to adjacent structures.

## Full-text entities

- **Diseases:** numbness (MESH:D006987), lymphoid and metastatic lesions (MESH:D000092182), benign lipoma (MESH:D008069), swelling (MESH:D004487), spindle-cell lipoma (MESH:D002277), soft tissue lesions (MESH:D012983), conventional lipomas (MESH:C563514), infection (MESH:D007239), angiolipoma (MESH:D018206), vascular lesions (MESH:D014652), adenocarcinoma (MESH:D000230), lymphangioma (MESH:D008202), benign tumor (MESH:D009369), oncocytoma (MESH:D018249), pain (MESH:D010146), Lipomatous lesions (MESH:D008080), cheek swelling (MESH:C536084), buccal space swelling (MESH:D008158), Traumatic (MESH:D014947), facial nerve deficit (MESH:D005155), Lipomas (MESH:D008067), inflammatory (MESH:D007249), adenoid cystic carcinoma (MESH:D003528), hematoma (MESH:D006406), hamartoma (MESH:D006222), salivary gland benign and malignant neoplasms (MESH:D012468), neuroma (MESH:D009463), developmental lesions (MESH:D001848), cheek masses (MESH:C536030), neurofibroma (MESH:D009455), salivary duct carcinoma (MESH:D012465), cysts (MESH:D003560), BFP (MESH:D004620), herniation (MESH:D004677), dermoid and epidermoid cyst (MESH:D003884), acute trauma (MESH:D000208), hemangioma (MESH:D006391), mucoepidermoid carcinoma (MESH:D018277), basal cell adenoma (MESH:D000236), mesenchymal tumors (MESH:C535700), carcinoma ex pleomorphic adenoma (MESH:D008949), fibroma (MESH:D005350), lymphadenopathy (MESH:D008206), acinic cell carcinoma (MESH:D018267), lesion (MESH:D009059)
- **Chemicals:** epinephrine (MESH:D004837), hematoxylin (MESH:D006416), eosin (MESH:D004801), gadolinium (MESH:D005682)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12921958/full.md

## References

34 references — full list in the complete paper: https://tomesphere.com/paper/PMC12921958/full.md

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Source: https://tomesphere.com/paper/PMC12921958