# Integrative Use of Cannabidiol, Melatonin, and Oxygen–Ozone Therapy in Triple-Negative Breast Cancer with Lung and Mediastinal Metastases. A Case Report

## TL;DR

A patient with aggressive breast cancer achieved long-term remission using a combination of standard treatment and supplements like melatonin, cannabidiol, and ozone therapy.

## Contribution

This case report suggests that integrative therapies may support remission in aggressive metastatic breast cancer.

## Key findings

- The patient's lung nodules disappeared after three months of integrative treatment.
- Combining integrative therapy with radiotherapy and immunotherapy led to a durable remission.
- The patient remained disease-free for five years following metastasis diagnosis.

## Abstract

Background and Clinical Significance: Breast cancer is the most frequent malignancy in women. Metastatic breast cancer is considered a treatable but incurable condition, with a median overall survival of only 2–3 years. Among its subtypes, triple-negative breast cancer (TNBC) accounts for a high proportion of breast cancer-related deaths. It is characterized by an aggressive clinical course, early recurrence, and a strong propensity for visceral and brain metastases. Case Presentation: We report the case of a Caucasian woman who developed systemic disease recurrence with lung and mediastinal lymph node metastases, occurring two years after her primary diagnosis and treatment for TNBC. The patient received three months of chemotherapy combined with an adjuvant integrative protocol consisting of melatonin, cannabidiol, and oxygen–ozone therapy. This combined approach led to the complete disappearance of the lung nodules. Subsequently, stereotactic radiotherapy was performed and, in association with the ongoing integrative treatment, resulted in a significant reduction in mediastinal adenopathy. Introduction of immunotherapy, supported continuously by the same adjuvant strategy, achieved a complete and durable remission. Strikingly, the patient remained disease-free five years after the diagnosis of lung and mediastinal metastases. Conclusions: This clinical case highlights the potential benefit of using melatonin, cannabidiol, and oxygen–ozone therapy as part of an integrative approach in patients with aggressive metastatic TNBC. While it is not possible to establish causality from a single case, the sustained remission observed suggests that such unconventional adjuvant strategies could play a supportive role in enhancing the efficacy of standard oncologic therapies.