# Anaphylaxis Following a Mouse Bite in a Patient Sensitized to Mouse, Rat, and Hamster: A Case Report

## TL;DR

A man developed anaphylaxis after a mouse bite, despite being sensitized to other rodents he hadn't directly handled.

## Contribution

This case report highlights sensitization and cross-reactivity among rodent allergens in a laboratory worker.

## Key findings

- The patient had specific IgE to mouse, rat, and hamster allergens despite only handling mice.
- Anaphylaxis occurred after a mouse bite, indicating sensitization from prior exposure.
- The case emphasizes the need for preventive measures and further research on rodent allergen cross-reactivity.

## Abstract

We report a case of anaphylaxis in a man in his 30s following a mouse bite while working in an animal research facility. He developed generalized erythema, wheezing, and hypoxemia consistent with grade 2 anaphylaxis, which resolved after treatment with adrenaline, corticosteroids, antihistamines, and bronchodilators. Serum testing revealed specific IgE to mouse, rat, and hamster, despite no direct exposure to the latter two species. The patient had worked as an animal researcher for 15 years, exclusively handling mice. Before this episode, he reported mouse bites occurring every two to three years, which caused only localized itching. This case highlights the need for preventive measures in laboratory settings and for further investigation into sensitization routes and the potential cross-reactivity among rodent allergens.