# The Role of L-Arginine and Liposomal Vitamin C Supplementation as an Adjunct in Seasonal Respiratory Viral Infection Recovery

**Authors:** Valentina Trimarco, Paola Gallo, Seyedali Ghazihosseini, Alessia Izzo, Paola Ida Rozza, Alessandra Spinelli, Stefano Cristiano, Carlo De Rosa, Felicia Rozza, Carmine Morisco

PMC · DOI: 10.3390/arm94010011 · Advances in Respiratory Medicine · 2026-02-09

## TL;DR

This paper explores how L-Arginine and Liposomal Vitamin C may help reduce symptoms of seasonal respiratory viral infections by targeting inflammation and oxidative stress.

## Contribution

The paper evaluates the potential of combining L-Arginine and Liposomal Vitamin C as an adjunct treatment for respiratory viral infections.

## Key findings

- L-Arginine and Vitamin C interfere with viral-induced inflammation.
- The combination may mitigate symptoms during acute and post-acute phases of infection.
- Nutritional support can contribute to symptom relief in respiratory viral infections.

## Abstract

What are the main findings?
Many respiratory viruses are able to induce endothelial dysfunction.L-Arginine and Vitamin C interfere with the viral-induced inflammatory response

Many respiratory viruses are able to induce endothelial dysfunction.

L-Arginine and Vitamin C interfere with the viral-induced inflammatory response

What are the implications of the main findings?
The combination of L-Arginine and Vitamin C seems to represent a nutritional support able to relieve the clinical symptoms of respiratory seasonal viral infection.

The combination of L-Arginine and Vitamin C seems to represent a nutritional support able to relieve the clinical symptoms of respiratory seasonal viral infection.

Respiratory seasonal viral infections remain one of the most important issues in community medicine. The heterogeneity of etiological agents and the characteristics of the hosts airway antiviral defenses account for the complex management of these infections. The clinical consequence of this picture is that, despite the widespread use of vaccination as the primary prevention strategy, the rates of acute respiratory complications remain still high. In addition, they determine post-infectious fatigue and organ dysfunction. Inflammation and oxidative stress are the principal pathogenic mechanisms responsible for clinical complications during respiratory seasonal viral infections. Nowadays, a growing body of evidence indicates that adjunctive nutritional support can contribute to relieve the symptoms during the acute and subacute phases of respiratory viral infections. We assess the data in the literature regarding the combination of L-Arginine and Liposomal Vitamin C as adjuvant treatment for respiratory seasonal viral infections. The database of the National Library of Medicine (PubMed) was searched using the keywords “L-Arginine, Vitamin C, dietary supplements, seasonal respiratory viral infections”. The treatment of symptoms during acute and post-acute respiratory viral infections requires an integrated approach that includes vitamins and nutritional supplementation. The combination of L-Arginine and Liposomal Vitamin C seems to represent a nutritional support able to mitigate symptoms occurring during the acute or post-acute phase of infection.

## Linked entities

- **Chemicals:** L-Arginine (PubChem CID 232), Vitamin C (PubChem CID 54670067)

## Full-text entities

- **Genes:** IL2 (interleukin 2) [NCBI Gene 3558] {aka IL-2, TCGF, lymphokine}, NOS2 (nitric oxide synthase 2) [NCBI Gene 4843] {aka HEP-NOS, INOS, NOS, NOS2A}, NOS3 (nitric oxide synthase 3) [NCBI Gene 4846] {aka EC-NOS, ECNOS, MYMY8, NOSIII, cNOS, eNOS}, IFNG (interferon gamma) [NCBI Gene 3458] {aka IFG, IFI, IMD69}, IL10 (interleukin 10) [NCBI Gene 3586] {aka CSIF, GVHDS, IL-10, IL10A, TGIF}, IL6 (interleukin 6) [NCBI Gene 3569] {aka BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2}, NFE2L2 (NFE2 like bZIP transcription factor 2) [NCBI Gene 4780] {aka IMDDHH, NRF2, Nrf-2}, MPO (myeloperoxidase) [NCBI Gene 4353]
- **Diseases:** fatigue (MESH:D005221), pneumonia (MESH:D011014), respiratory (MESH:D012131), obese (MESH:D009765), organ dysfunction (MESH:D009102), Long COVID (MESH:D000094024), sepsis (MESH:D018805), asthenia (MESH:D001247), airway obstruction (MESH:D000402), post-acute (MESH:D013313), fever (MESH:D005334), acute respiratory distress syndrome (MESH:D012128), lower-respiratory-tract diseases (MESH:D012140), deaths (MESH:D003643), influenza (MESH:D007251), pain (MESH:D010146), Viral Infections (MESH:D014777), corona virus infections (MESH:D018352), Inflammation (MESH:D007249), respiratory infections (MESH:D012141), injury to (MESH:D014947), thrombosis (MESH:D013927), gastrointestinal side effects (MESH:D064420), cough (MESH:D003371), lung injury (MESH:D055370), dyspnea (MESH:D004417), infection (MESH:D007239), Endothelial Dysfunction (MESH:D014652), COVID-19 (MESH:D000086382)
- **Chemicals:** Vitamin A (MESH:D014801), NO (MESH:D009569), ROS (MESH:D017382), colchicine (MESH:D003078), N-acetyl cysteine (MESH:D000111), citrulline (MESH:D002956), Ascorbic Acid (MESH:D001205), Bioarginina  C (-), Vitamin D (MESH:D014807), deferoxamine (MESH:D003676), Arginine (MESH:D001120), NADPH (MESH:D009249)
- **Species:** Gammacoronavirus (genus) [taxon 694013], Severe acute respiratory syndrome coronavirus 2 (no rank) [taxon 2697049], Orthomyxoviridae (family) [taxon 11308], Respiratory syncytial virus (no rank) [taxon 12814], Enterovirus (genus) [taxon 12059], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12921747/full.md

## References

32 references — full list in the complete paper: https://tomesphere.com/paper/PMC12921747/full.md

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Source: https://tomesphere.com/paper/PMC12921747