# The Added Value of 4D‐Flow CMR: Identifying Aortic Regurgitation as the Culprit for Severe Cardiomyopathy

**Authors:** Alexander Gall, Pankaj Garg

PMC · DOI: 10.1002/ccr3.72074 · Clinical Case Reports · 2026-02-20

## TL;DR

4D-flow CMR can better detect severe aortic regurgitation than standard methods, helping guide timely treatment.

## Contribution

Demonstrates the added diagnostic value of 4D-flow CMR in reclassifying aortic regurgitation severity.

## Key findings

- Standard echocardiography and 2D CMR may underestimate aortic regurgitation severity.
- 4D-flow CMR reclassified AR severity, revealing a significant pathology.
- The technique aids in guiding timely clinical intervention.

## Abstract

Hemodynamically significant aortic regurgitation (AR) may be underestimated by standard echocardiography and 2D phase‐contrast CMR, particularly in patients with heart rate variability. This case highlights the additive role of 4D‐flow CMR in reclassifying AR severity, thereby identifying a significant pathology and helping to guide timely intervention.

## Linked entities

- **Diseases:** cardiomyopathy (MONDO:0004994)

## Full-text entities

- **Diseases:** shortness of breath (MESH:D004417), LGE (MESH:C564835), volume overload (MESH:D019190), myocardial fibrosis (MESH:D005355), Cardiomyopathy (MESH:D009202), heart failure (MESH:D006333), breast cancer (MESH:D001943), AR (MESH:D001022), LV dilation (MESH:D020257), systolic dysfunction (MESH:D006331)
- **Chemicals:** furosemide (MESH:D005665), dapagliflozin (MESH:C529054), ramipril (MESH:D017257), bisoprolol (MESH:D017298), spironolactone (MESH:D013148)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12921623/full.md

## References

3 references — full list in the complete paper: https://tomesphere.com/paper/PMC12921623/full.md

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Source: https://tomesphere.com/paper/PMC12921623