# Intestinal Stenosis Secondary to Grade IV Endometriosis: A Case Report

**Authors:** Quitzia M Rentería Fonseca, Alma D Franco Jiménez, Martha Bramasco Mendoza, Cristino Coyac Aguilar

PMC · DOI: 10.7759/cureus.101965 · Cureus · 2026-01-21

## TL;DR

A 41-year-old woman with severe endometriosis developed intestinal stenosis, highlighting the need for early diagnosis and multidisciplinary care.

## Contribution

This case report provides a detailed clinical pathway for diagnosing and treating intestinal stenosis caused by grade IV endometriosis.

## Key findings

- Colonoscopy and CT imaging identified intestinal stenosis with intact mucosa and wall thickening.
- Histopathology confirmed endometrial tissue infiltration into the bowel wall without atypia.
- Multidisciplinary treatment led to symptom improvement and no immediate complications.

## Abstract

Intestinal stenosis secondary to deep endometriosis grade four is an uncommon presentation that often leads to delayed diagnosis and challenging therapeutic decisions. We report the case of a 41-year-old woman with long-standing pelvic pain, dysmenorrhea, and alternating constipation and diarrhea, with a history of surgery for endometriosis. The aim is to describe the diagnostic and therapeutic pathway and to highlight practical lessons for clinical care. Clinical assessment and blood tests revealed mild anemia. Colonoscopy showed a narrowed sigmoid colon with intact mucosa, and contrast-enhanced computed tomography demonstrated an abrupt caliber transition and focal wall thickening. Management consisted of a multidisciplinary-planned segmental intestinal resection. Histopathology confirmed endometrial glands and stroma infiltrating the muscular layer with fibrosis and no atypia. Follow-up documented improvement of obstructive symptoms and absence of immediate complications. This case contributes an integrated view of endoscopic, radiologic, and pathological findings explaining stenosis caused by extrinsic involvement of the bowel wall. The key lesson is to maintain a high index of suspicion for intestinal endometriosis in women of reproductive age with cyclic gastrointestinal symptoms and stenosis without mucosal disease, emphasizing multidisciplinary evaluation and histological confirmation to timely define surgical treatment.

## Linked entities

- **Diseases:** endometriosis (MONDO:0005133), anemia (MONDO:0002280)

## Full-text entities

- **Genes:** MUC16 (mucin 16, cell surface associated) [NCBI Gene 94025] {aka CA125}
- **Diseases:** gynecological disease (MESH:D005831), abdominal distension (MESH:D000007), inflammatory bowel disease (MESH:D015212), irritable bowel syndrome (MESH:D043183), rASRM (MESH:C000719191), tenderness (MESH:D063806), constipation (MESH:D003248), rectal pain (MESH:C563475), stenosis of the gastrointestinal tract (MESH:D005770), intestinal obstruction (MESH:D007415), Intestinal Stenosis (MESH:D007410), ovarian (MESH:D010049), acute abdomen (MESH:D000006), chronic pelvic pain (MESH:D011472), sigmoid stenosis (MESH:D012810), anemia (MESH:D000740), acute appendicitis (MESH:D001064), colonic stenosis (MESH:D015179), dysmenorrhea (MESH:D004412), pelvic pain (MESH:D017699), adhesions (MESH:D000267), gastrointestinal conditions (MESH:D005767), infertility (MESH:D007246), Crohn's disease (MESH:D003424), retroverted uterus (MESH:D060725), dyspareunia (MESH:D004414), ulceration (MESH:D014456), arthralgia (MESH:D018771), bleeding (MESH:D006470), pelvic disease (MESH:D000292), diarrhea (MESH:D003967), fever (MESH:D005334), intestinal stricture (MESH:D003251), functional bowel disorders (MESH:D000079689), fibrosis (MESH:D005355), bowel involvement (MESH:D012778), mucosal disease (MESH:D004194), Gastrointestinal symptoms (MESH:D012817), hot flashes (MESH:D019584), DIE (MESH:D004715), pain (MESH:D010146), colorectal neoplasia (MESH:D009369), rectal bleeding (MESH:D012002), abdominal pain (MESH:D015746)
- **Chemicals:** alcohol (MESH:D000438), lysine (MESH:D008239), glucose (MESH:D005947), gonadotropin-releasing hormone agonist (-), pargeverine (MESH:C087283), etoricoxib (MESH:D000077613), mefenamic acid (MESH:D008528), levonorgestrel (MESH:D016912), dexketoprofen (MESH:C118296)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12921534/full.md

## References

11 references — full list in the complete paper: https://tomesphere.com/paper/PMC12921534/full.md

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Source: https://tomesphere.com/paper/PMC12921534