# Morphological and Dynamic Contrast-Enhanced MRI Characteristics of Breast Imaging Reporting and Data System (BI-RADS) 3 and Above Breast Masses With Color Doppler and Histopathological Correlation

**Authors:** Shivya Parashar, Sangeeta Saxena, Jitendra Sharma, Sanjeev Shukla

PMC · DOI: 10.7759/cureus.101957 · Cureus · 2026-01-21

## TL;DR

This study examines MRI features of breast masses rated BI-RADS 3 or higher, comparing imaging results with histopathology to improve cancer diagnosis.

## Contribution

The study combines MRI morphology, enhancement kinetics, and DWI to achieve high diagnostic accuracy for possibly malignant breast lesions.

## Key findings

- MRI showed high sensitivity for malignant features like irregular margins and washout patterns.
- DWI significantly improved the specificity of breast mass diagnosis.
- Color Doppler had limited utility, with diagnostic value only when resistive index exceeded 0.7.

## Abstract

This prospective study evaluated the morphological characteristics, enhancement patterns, and diffusion-weighted imaging (DWI) features of Breast Imaging Reporting and Data System (BI-RADS) 3 and above breast masses on MRI, correlated the imaging findings with color Doppler, and assessed diagnostic performance. Thirty-eight women underwent ultrasound, color Doppler, and breast MRI with DWI, with imaging findings compared against histopathology as the reference standard. MRI demonstrated high sensitivity for malignant features, including irregular margins, heterogeneous or rim enhancement, and washout kinetic patterns. The addition of DWI significantly improved specificity. Color Doppler showed limited diagnostic utility, with meaningful diagnostic value primarily observed when the resistive index exceeded 0.7. The combined evaluation of MRI morphology, enhancement kinetics, and DWI provides high diagnostic accuracy in possibly malignant breast lesions.

## Linked entities

- **Diseases:** breast cancer (MONDO:0004989)

## Full-text entities

- **Genes:** BRCA1 (BRCA1 DNA repair associated) [NCBI Gene 672] {aka BRCAI, BRCC1, BROVCA1, FANCS, IRIS, PNCA4}
- **Diseases:** edema (MESH:D004487), vascular lesion (MESH:D014652), benign (MESH:D009369), cervical cancer (MESH:D002583), fibroadenoma (MESH:D018226), invasive lobular carcinoma (MESH:D018275), Breast Masses (MESH:D061325), benign lesions (MESH:D001932), Stage III or IV (MESH:D062706), malignant breast lesions (MESH:D001941), IDC (MESH:D044584), female (MESH:D005831), renal impairment (MESH:D007674), Breast cancer (MESH:D001943)
- **Chemicals:** gadopentetate dimeglumine (MESH:D019786), DCE (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12921424/full.md

## References

17 references — full list in the complete paper: https://tomesphere.com/paper/PMC12921424/full.md

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Source: https://tomesphere.com/paper/PMC12921424