# Commentary: Undifferentiated pleomorphic sarcoma of the adrenal gland: a case report and literature review

**Authors:** Tomonori Kawasaki, Takuya Watanabe, Masataka Hirasaki, Satoshi Kanno, Ryuzo Kawamura, Arisa Kokubo, Shinji Furuya, Masanori Wako, Jiro Ichikawa

PMC · DOI: 10.3389/fonc.2026.1685761 · Frontiers in Oncology · 2026-02-05

## Full-text entities

- **Genes:** MDM2 (MDM2 proto-oncogene) [NCBI Gene 4193] {aka ACTFS, HDMX, LSKB, hdm2}, ETFA (electron transfer flavoprotein subunit alpha) [NCBI Gene 2108] {aka EMA, GA2, MADD}, ACTA1 (actin alpha 1, skeletal muscle) [NCBI Gene 58] {aka ACTA, ASMA, CFTD, CFTD1, CFTDM, CMYO2A}, CD34 (CD34 molecule) [NCBI Gene 947], SMN1 (survival of motor neuron 1, telomeric) [NCBI Gene 6606] {aka BCD541, GEMIN1, SMA, SMA1, SMA2, SMA3}, CDKN2A (cyclin dependent kinase inhibitor 2A) [NCBI Gene 1029] {aka ARF, CAI2, CDK4I, CDKN2, CMM2, INK4}, MYOD1 (myogenic differentiation 1) [NCBI Gene 4654] {aka CMYO17, CMYP17, MYF3, MYOD, MYODRIF, PUM}, MYOG (myogenin) [NCBI Gene 4656] {aka MYF4, bHLHc3, myf-4}, HMBS (hydroxymethylbilane synthase) [NCBI Gene 3145] {aka ENCEP, LENCEP, PBG-D, PBGD, PORC, UPS}, DES (desmin) [NCBI Gene 1674] {aka CDCD3, CSM1, CSM2, LGMD1D, LGMD1E, LGMD2R}, CDK4 (cyclin dependent kinase 4) [NCBI Gene 1019] {aka CMM3, MCPH31, PSK-J3}
- **Diseases:** DDLPS (MESH:D008080), LMS (MESH:D007890), Undifferentiated pleomorphic sarcoma (MESH:D002277), carcinoma (MESH:D009369), malignant fibrous histiocytoma (MESH:D051677), PRMS (MESH:D012208), nonlipogenic sarcomas (MESH:D012509), Undifferentiated pleomorphic sarcoma of the adrenal gland (MESH:D000307), metastases (MESH:D009362), sarcomatoid (MESH:D002292)
- **Chemicals:** anthracyclines (MESH:D018943), ifosfamide (MESH:D007069), docetaxel (MESH:D000077143), gemcitabine (MESH:D000093542)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

17 references — full list in the complete paper: https://tomesphere.com/paper/PMC12921359/full.md

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Source: https://tomesphere.com/paper/PMC12921359