# Systemic multiple thrombosis caused by double homozygous mutations of PAI-1 4G/4G and MTHFR C677T during pregnancy

**Authors:** Hongcen Pan, Jinmi Li, Wenjun Zhu, Ruoxu Li, Jinan Jiang, Qing Huang

PMC · DOI: 10.1007/s44313-026-00124-7 · Blood Research · 2026-02-19

## Full-text entities

- **Genes:** CGB5 (chorionic gonadotropin subunit beta 5) [NCBI Gene 93659] {aka CGB, HCG}, MTHFR (methylenetetrahydrofolate reductase) [NCBI Gene 4524], SERPINE1 (serpin family E member 1) [NCBI Gene 5054] {aka PAI, PAI-1, PAI1, PLANH1}
- **Diseases:** gastroenteritis (MESH:D005759), VTE (MESH:D054556), multiple thrombosis (MESH:D013927), portal vein thrombosis (MESH:D012170), appendicitis (MESH:D001064), inflammatory (MESH:D007249), ascites (MESH:D001201), trauma (MESH:D014947), liver fibrosis (MESH:D008103), abdominal pain (MESH:D015746), venous thrombosis (MESH:D020246), cerebral infarction (MESH:D002544), thrombocytopenia (MESH:D013921), infection (MESH:D007239), coagulation (MESH:D001778), hypercoagulable (MESH:D019851), hereditary thrombophilia (MESH:C540694), hyperhomocysteinemia (MESH:D020138), vomiting (MESH:D014839), acute abdomen (MESH:D000006), gastrointestinal bleeding (MESH:D006471), necrosis (MESH:D009336), pulmonary embolism (MESH:D011655)
- **Chemicals:** enoxaparin sodium (MESH:C000711671), rivaroxaban (MESH:D000069552), enoxaparin (MESH:D017984), Heparin (MESH:D006493)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Mutations:** 677TT

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Source: https://tomesphere.com/paper/PMC12920837