# Identification of risk factors and development of a multivariable prognostic prediction model for incontinence-associated dermatitis in older nursing home residents

**Authors:** Monira El Genedy-Kalyoncu, Bettina Völzer, Jan Kottner

PMC · DOI: 10.1038/s41598-026-40416-7 · Scientific Reports · 2026-02-18

## TL;DR

This study identifies risk factors for incontinence-associated dermatitis in older nursing home residents and develops a predictive model to help prevent the condition.

## Contribution

The study introduces a new multivariable prognostic model for predicting incontinence-associated dermatitis in older adults.

## Key findings

- Lower Barthel Index scores, severe mobility impairment, and absence of xerosis on the legs are significant predictors of IAD.
- The model shows good discrimination with an area under the curve of 0.82 and satisfactory calibration.
- The protective effect of higher functional independence is reduced in residents with double incontinence.

## Abstract

Incontinence-associated dermatitis (IAD) is an inflammatory skin condition caused by prolonged exposure of the skin to urine and feces. It is common among older adults in long-term care and contributes to pain, discomfort, and increased risk for secondary infection. This study aimed to identify risk factors for IAD development and to construct a prognostic model for incontinent nursing home residents aged ≥ 65 years. A secondary analysis was conducted using data from a cluster-randomized controlled clinical trial performed in Berlin, Germany (April 2019 to June 2021). A total of 149 incontinent residents were included. At week 12, 20 residents (13.4%) newly developed IAD. The final cluster-adjusted multivariable model identified lower Barthel Index scores, severe mobility impairment, and the absence of xerosis on the legs as significant predictors. An interaction between double incontinence and Barthel Index scores indicated that the protective effect of higher functional independence was reduced in residents with double incontinence. The model demonstrated good discrimination (area under the curve 0.82), sensitivity of 78.6%, specificity of 74.2%, and satisfactory calibration (Hosmer-Lemeshow test p = 0.67). These findings support early risk identification and targeted prevention; validation in a prospective cohort is warranted to confirm the model’s robustness and clinical utility.

The online version contains supplementary material available at 10.1038/s41598-026-40416-7.

## Full-text entities

- **Genes:** REN (renin) [NCBI Gene 5972] {aka ADTKD4, HNFJ2, RTD}
- **Diseases:** Xerosis cutis (MESH:D000092182), paralytic syndromes (MESH:D000092164), Functional dependency (MESH:D019966), Alzheimer's disease (MESH:D000544), water loss (MESH:D000069578), weakness (MESH:D018908), pain (MESH:D010146), sleep disturbance (MESH:D012893), inflammatory skin condition (MESH:D012871), itch (MESH:D011537), mobility limitations (MESH:D051346), xerosis of the legs (MESH:D010264), Dermatitis (MESH:D003872), overweight (MESH:D050177), hemiparesis (MESH:D010291), Dry Skin (MESH:D015352), infection (MESH:D007239), skin fragility (MESH:C536183), COVID-19 (MESH:D000086382), malnutrition (MESH:D044342), mobility impairment (MESH:D014086), Pressure Injury (MESH:D003668), overhydration (MESH:D014869), inflammatory skin disorder (MESH:D012868), cognitive impairment (MESH:D003072), Deterioration (MESH:D000075902), Double incontinence (MESH:D014549), atopic dermatitis (MESH:D003876), Intertrigo (MESH:D007402), erythema (MESH:D004890), contact dermatitis (MESH:D003877), Dementia (MESH:D003704), hemiplegia (MESH:D006429), dryness (MESH:D014987), underweight (MESH:D013851), fecal incontinence (MESH:D005242)
- **Chemicals:** TEWL (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12920631/full.md

## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC12920631/full.md

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Source: https://tomesphere.com/paper/PMC12920631