# Influence of lower anterior crowding on the predictability of mandibular tooth movement in Invisalign therapy: a retrospective cohort analysis

**Authors:** Reem Y. Alulyan, Abdulaziz S. Alamri, Suliman Y. Shahin, Naif N. Almasoud, Essam A. Nassar, Osama A. Alsulaiman, Ahmed A. Alsulaiman

PMC · DOI: 10.3389/fdmed.2025.1727909 · Frontiers in Dental Medicine · 2026-02-06

## TL;DR

This study found that lower anterior crowding reduces the accuracy of Invisalign therapy, leading to discrepancies in tooth movement predictions.

## Contribution

The study identifies specific tooth movements affected by crowding and quantifies the relationship between crowding severity and prediction accuracy.

## Key findings

- Significant discrepancies were found between predicted and achieved tooth movements in crowded cases.
- Increased crowding correlated with greater rotational and linear movement differences in specific teeth.
- Overcorrection and additional tools are recommended for crowded cases to improve treatment outcomes.

## Abstract

Invisalign® can resolve up to 91.4% of mandibular incisor crowding. However, there is insufficient evidence to support clear aligner therapys effectiveness for various tooth movements. While the accuracy of Invisalign® has been evaluated, few studies have evaluated its efficacy in alleviating lower arch crowding. Hence, we aimed to identify significant differences between predicted and achieved linear, vertical, and rotational tooth movements in Class I mild-to-severe crowding cases. We also examined the association between lower anterior crowding and discrepancies in predicted vs. achieved movements.

This retrospective cohort study, conducted in Saudi Arabia, included 44 participants collected between May and September 2023. The treatment protocol involved proclination followed by interproximal reduction for lower mandibular crowding.

The sample comprised 63% female patients (mean age: 32). All anterior lower teeth showed significant discrepancies between predicted and achieved movement (3.64 ± 3.25). A significant positive relationship was observed between crowding and lower right canine linear/rotational movements, as well as lower left central/lateral linear movements,lower left lateral vertical and lower right lateral linear movement. Clinically, a one unit increase in crowding correlated with a 0.49 increase in lower right canine rotational difference, while a one unit increase in crowding corresponded to a 0.405 increase in lower right lateral rotational difference.

Dental crowding reduces the accuracy of clear aligner therapy. Clinically, overcorrection should be routine, and additional tools should be used to improve predictability in cases with significant crowding.

## Full-text entities

- **Diseases:** anterior mandibular crowding (MESH:D008338), Incisor (MESH:D057887), tooth movement (MESH:D014076), Dental crowding (MESH:D008310), anterior (MESH:D020759), systemic diseases (MESH:D034721), AAA (MESH:C565230)
- **Species:** Homo sapiens (human, species) [taxon 9606], Canis lupus familiaris (dog, subspecies) [taxon 9615]

## Full text

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## References

33 references — full list in the complete paper: https://tomesphere.com/paper/PMC12920432/full.md

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Source: https://tomesphere.com/paper/PMC12920432