# Commentary: Immuno-inflammatory signature for predicting therapeutic response and survival after stereotactic radiosurgery in NSCLC patients with brain metastases: a retrospective cohort study

**Authors:** Kunpeng Yang, Wenjuan Sun, Bao Wang

PMC · DOI: 10.3389/fimmu.2026.1782399 · Frontiers in Immunology · 2026-02-06

## Full-text entities

- **Genes:** EGFR (epidermal growth factor receptor) [NCBI Gene 1956] {aka ERBB, ERBB1, ERRP, HER1, NISBD2, NNCIS}, ALK (ALK receptor tyrosine kinase) [NCBI Gene 238] {aka ALK1, CD246, NBLST3}, CD8A (CD8 subunit alpha) [NCBI Gene 925] {aka CD8, CD8alpha, IMD116, Leu2, p32}, TXK (TXK tyrosine kinase) [NCBI Gene 7294] {aka BTKL, PSCTK5, PTK4, RLK, TKL}, VEGFA (vascular endothelial growth factor A) [NCBI Gene 7422] {aka L-VEGF, MVCD1, VEGF, VPF}
- **Diseases:** BM (MESH:D001932), brain metastasis (MESH:D009362), Vasogenic edema (MESH:D001929), NSCLC (MESH:D002289), NLR (MESH:D015467), inflammation (MESH:D007249), Cancer (MESH:D009369), Edema (MESH:D004487)
- **Chemicals:** FLAURA (-), bevacizumab (MESH:D000068258), osimertinib (MESH:C000596361)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

8 references — full list in the complete paper: https://tomesphere.com/paper/PMC12920427/full.md

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Source: https://tomesphere.com/paper/PMC12920427