# The anterior intercostal artery perforator flap in immediate oncoplastic breast reconstruction: current applications and future perspectives

**Authors:** Weijie Kong, Zhiyao Wang, Yang Liu, Jie Pei, Fan Guo

PMC · DOI: 10.3389/fonc.2026.1765679 · Frontiers in Oncology · 2026-02-06

## TL;DR

This paper reviews the use of the anterior intercostal artery perforator flap for breast reconstruction, highlighting its benefits and future research directions.

## Contribution

The paper provides a comprehensive review of the AICAP flap's anatomy, surgical design, and potential for improved breast reconstruction outcomes.

## Key findings

- AICAP flaps offer minimal donor-site morbidity and excellent scar concealment.
- They are particularly suitable for reconstructing defects in the lower and lower-inner breast quadrants.
- Standardized indications and long-term follow-up data are needed to strengthen clinical evidence.

## Abstract

In recent years, the anterior intercostal artery perforator (AICAP) flap has gained increasing attention for its minimal donor-site morbidity, natural contour, and excellent scar concealment. This review begins by outlining the vascular anatomy of the anterior intercostal perforators, including their distribution, perfusion characteristics, and key considerations for preoperative imaging. We then summarize the indications and limitations of other commonly used chest wall perforator flaps, such as the lateral intercostal artery perforator (LICAP) and thoracodorsal artery perforator (TDAP) flaps to contextualize the unique role of AICAP in partial breast reconstruction. Building on this foundation, we focus on the surgical design, harvest dimensions, arc of rotation, and anatomical relationship between AICAP flaps and the inframammary fold. Compared with traditional local flaps, AICAP flaps offer reliable vascularity, excellent tissue compliance, minimal donor-site disruption, and low rates of postoperative complications. Their location within a natural skin crease also allows the resulting scar to remain well concealed. These features make AICAP particularly suitable for precise reconstruction of defects in the lower and lower-inner breast quadrants, where long-term aesthetic stability is often difficult to achieve. Nonetheless, standardized indications, anatomical variability, limited sample sizes, and a lack of long-term follow-up continue to constrain the strength of current evidence. Overall, this review synthesizes the anatomical basis, technical considerations, clinical advantages, and existing limitations of the AICAP flap. We further highlight emerging directions—including image-guided perforator mapping, personalized flap design, and long-term outcome assessment—to support the development of more standardized and reproducible clinical pathways for AICAP-based breast reconstruction.

## Full-text entities

- **Genes:** VANGL2 (VANGL planar cell polarity protein 2) [NCBI Gene 57216] {aka LPP1, LTAP, STB1, STBM, STBM1}
- **Diseases:** systemic disease (MESH:D034721), capsular contracture (MESH:D003286), vasospasm (MESH:D020301), ischemia (MESH:D007511), scar (MESH:D002921), bleeding (MESH:D006470), obese (MESH:D009765), AICAP (MESH:D020759), anxiety (MESH:D001007), atrophy (MESH:D001284), Cancer (MESH:D009369), diabetes (MESH:D003920), skin (MESH:D012871), dehiscence (MESH:D013529), torsion (MESH:D050723), Hematomas (MESH:D006406), seroma (MESH:D049291), fibrosis (MESH:D005355), volume loss (MESH:D016388), inflammatory (MESH:D007249), necrosis (MESH:D009336), oncologic (MESH:D000072716), TDAP (MESH:D057112), depression (MESH:D003866), T1-T2 breast cancers (MESH:D001943), female (MESH:D005831), fat necrosis (MESH:D005218), deformity (MESH:D009140), IMF (MESH:D057165), ptosis (MESH:C564553), T3-T4 tumors (MESH:D005067), Postoperative complications (MESH:D011183), infection (MESH:D007239), breast defects (MESH:D061325), volume deficiency (MESH:D007153)
- **Chemicals:** ICG (MESH:D007208)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12920241/full.md

## References

68 references — full list in the complete paper: https://tomesphere.com/paper/PMC12920241/full.md

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Source: https://tomesphere.com/paper/PMC12920241