# Effects of enzyme preparations on growth performance, meat quality, and hepatic transcriptome of yaks

**Authors:** Yongfu La, Xiaoming Ma, Runli Wang, Futao Mo, Minghui Zhao, Yan Yang, Xuemei Liu, Maji Wan, Pengjia Bao, Min Chu, Xian Guo, Ping Yan, Chunnian Liang

PMC · DOI: 10.3389/fvets.2026.1707381 · Frontiers in Veterinary Science · 2026-02-06

## TL;DR

Adding enzyme preparations to yak diets improves growth without affecting meat quality, possibly by altering fatty acid metabolism in the liver.

## Contribution

This study demonstrates the impact of enzyme preparations on yak growth and fatty acid metabolism through production performance and transcriptome analysis.

## Key findings

- Adding 0.20% enzyme preparation increases average daily gain and reduces feed conversion rate.
- Enzyme preparations cause differential expression of fatty acid metabolism-related genes in the liver.
- Meat quality remains unaffected despite changes in liver gene expression and fatty acid composition.

## Abstract

The balance between grass and livestock has exacerbated the problem of high-quality development in the yak industry, and the nutritional regulation of enzyme preparations has become a research hotspot. The purpose of this study was to assess and contrast the effects of feeding with various concentrations of enzyme preparations of yaks, including the production performance, meat quality, fatty acid composition of the longissimus dorsi muscle, and gene expression. Adding 0.20% enzyme preparation to the diet can significantly increase the average daily gain (ADG), and reduce the dry matter intake (DMI) and feed conversion rate (FCR), but has no significant effect on the meat quality of yak. In addition, the liver transcriptome and muscle metabolize showed that the addition of enzyme preparations caused differential expression of fatty acid metabolism-related genes in the liver, which may affect the metabolism of fatty acids in the liver and thus alter the fatty acid composition in the longissimus dorsi muscle of yak. The results of this study emphasize that adding enzyme preparations can improve the production performance of yaks without affecting their meat quality, thereby enhancing the economic benefits of yak breeding.

## Full-text entities

- **Diseases:** ACADM deficiency (MESH:C536038), weight gain (MESH:D015430), XL (MESH:D000080345), DM (MESH:D009223)
- **Chemicals:** Oleic acid (MESH:D019301), short-chain fatty acids (MESH:D005232), cholesterol (MESH:D002784), water (MESH:D014867), unsaturated fats (MESH:D005224), IS (MESH:D007455), lipid (MESH:D008055), arachidonic acid (MESH:D016718), acetyl-CoA (MESH:D000105), LP (MESH:D008070), nitrogen (MESH:D009584), lactose (MESH:D007785), lactic acid (MESH:D019344), carbohydrate (MESH:D002241), acetone (MESH:D000096), Fatty acid (MESH:D005227), monounsaturated fatty acid (MESH:D005229), ketone (MESH:D007659), MP (MESH:C063925), triglyceride (MESH:D014280), methanol (MESH:D000432), Linoleic acid (MESH:D019787), -, and long-chain fatty acids (-), PUFA (MESH:D005231)
- **Species:** Bos grunniens (domestic yak, species) [taxon 30521], Bos taurus (bovine, species) [taxon 9913], Aspergillus oryzae (species) [taxon 5062], Homo sapiens (human, species) [taxon 9606], Aspergillus niger (species) [taxon 5061], Glycine max (soybean, species) [taxon 3847]

## Full text

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## Figures

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## References

42 references — full list in the complete paper: https://tomesphere.com/paper/PMC12920232/full.md

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Source: https://tomesphere.com/paper/PMC12920232