# Is (critical) health literacy a key to better psychosomatic functioning in patients with inflammatory bowel disease? Testing a mediation model

**Authors:** Orsolya Papp-Zipernovszky, Barbara Horvát, Anett Dávid, Beatrix Rafael, Sanela Tóth-Njers, Dávid Strausz, Mátyás Gyóllai, Tamás Molnár, Viola Sallay, Barna Konkolÿ Thege, Tamás Martos

PMC · DOI: 10.3389/fpsyt.2026.1643641 · Frontiers in Psychiatry · 2026-02-06

## TL;DR

The study explores how health literacy and self-efficacy affect symptom severity and life satisfaction in inflammatory bowel disease patients, especially those with depression.

## Contribution

The paper introduces a novel mediation model linking critical health literacy, health self-efficacy, and psychosomatic outcomes in IBD patients.

## Key findings

- Critical health literacy boosts health self-efficacy, which reduces symptom severity and increases life satisfaction.
- These effects are stronger in patients with elevated depression or during disease relapse.
- No differences were found between Crohn’s disease and ulcerative colitis patients in the model’s effects.

## Abstract

Chronic illnesses such as inflammatory bowel disease (IBD) require continuous self-management, often under emotionally and physically taxing conditions. While health literacy and health self-efficacy are known to support disease adaptation, their combined role in psychosomatic functioning, especially under varying levels of depression, remains underexplored. This study examined how health literacy, health self-efficacy, and depressive symptoms influence symptom severity and life satisfaction in patients with IBD.

A cross-sectional survey of 393 patients with IBD (60.7% with Crohn’s disease; 56% female; mean age = 40.75) was conducted at a gastroenterology outpatient clinic in Hungary. Standardized questionnaires assessed health literacy, health self-efficacy, depression, symptom severity, and satisfaction with life. Structural equation modeling was used to test a mediation model. Multigroup analyses explored the stability of the model across subgroups defined by depressive symptom levels, disease status (relapse vs. remission), and types of diseases.

Critical health literacy predicted higher health self-efficacy, which was associated with lower symptom severity and, in turn, greater life satisfaction. This indirect pathway remained significant after controlling demographic variables. Multigroup analyses showed that these relationships were stronger among patients in relapse and those with elevated depression, suggesting increased psychological sensitivity in these subgroups. No difference was found between types of disease.

The findings underscore the importance of critical health literacy and health self-efficacy as interconnected psychological resources in chronic illness self-management. Strengthening these capacities may reduce symptom burden and enhance well-being, particularly in times of relapse and periods of psychological vulnerability. The results support a shift toward integrated, psychosocially informed care models for IBD.

## Linked entities

- **Diseases:** inflammatory bowel disease (MONDO:0005265), Crohn’s disease (MONDO:0005011)

## Full-text entities

- **Genes:** INS (insulin) [NCBI Gene 3630] {aka IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10}
- **Diseases:** nausea (MESH:D009325), bleeding (MESH:D006470), mental health problems (MESH:D000076082), diarrhea (MESH:D003967), vitamin D deficiency (MESH:D014808), fatigue (MESH:D005221), chronic obstructive pulmonary disease (MESH:D029424), chest pain (MESH:D002637), arthritic symptoms (MESH:D015535), vomiting (MESH:D014839), HL (MESH:C538324), headache (MESH:D006261), abscesses (MESH:D000038), inflammation (MESH:D007249), sleep problems (MESH:D012893), pain (MESH:D010146), diabetes (MESH:D003920), mental disorders (MESH:D001523), shortness of breath (MESH:D004417), Anxiety, Stress (MESH:D001007), Depression (MESH:D003866), IBD (MESH:D015212), T2DM (MESH:D003924), stomach pain (MESH:D013272), heart palpitation (MESH:D006331), constipation (MESH:D003248), immune-mediated diseases of the gastrointestinal tract (MESH:D005770), indigestion (MESH:D004415), Chronic illnesses (MESH:D002908), ulcerative colitis (MESH:D003093), anemia (MESH:D000740), back pain (MESH:D001416), malabsorption disorders (MESH:D008286), colitis ulcerosa (MESH:D003092), Crohn's (MESH:D003424), dizziness (MESH:D004244), arm/leg or joint pain (MESH:D018771), weight loss (MESH:D015431)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12920207/full.md

## References

52 references — full list in the complete paper: https://tomesphere.com/paper/PMC12920207/full.md

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Source: https://tomesphere.com/paper/PMC12920207