# Editorial: Unraveling inflammatory pathways in sickle cell disease: molecular, cellular and translational insights

**Authors:** Nicola Conran, Subarna Chakravorty, Renata Sesti-Costa

PMC · DOI: 10.3389/fimmu.2026.1796628 · Frontiers in Immunology · 2026-02-06

## Full-text entities

- **Genes:** SIRPA (signal regulatory protein alpha) [NCBI Gene 140885] {aka BIT, CD172A, MFR, MYD-1, MYD1, P84}, HMOX1 (heme oxygenase 1) [NCBI Gene 3162] {aka HMOX1D, HO-1, HSP32, bK286B10}, MRC1 (mannose receptor C-type 1) [NCBI Gene 4360] {aka CD206, CLEC13D, CLEC13DL, MMR, MRC1L1, bA541I19.1}, VCAM1 (vascular cell adhesion molecule 1) [NCBI Gene 7412] {aka CD106, INCAM-100}, HBB (hemoglobin subunit beta) [NCBI Gene 3043] {aka CD113t-C, ECYT6, beta-globin}
- **Diseases:** SCD (MESH:D000755), vascular dysfunction (MESH:D002561), vaso-occlusion (MESH:D001157), hemolysis (MESH:D006461), red blood cell (RBC) disorder (MESH:C562718), ischemia (MESH:D007511), blood vessel obstruction (MESH:D009383), vaso-occlusive crises (MESH:D013224), pain (MESH:D010146), inflammatory (MESH:D007249)
- **Chemicals:** hydroxyurea (MESH:D006918), heme (MESH:D006418), iron (MESH:D007501)
- **Species:** Homo sapiens (human, species) [taxon 9606], Mus musculus (house mouse, species) [taxon 10090]

## Full text

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## References

15 references — full list in the complete paper: https://tomesphere.com/paper/PMC12920193/full.md

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Source: https://tomesphere.com/paper/PMC12920193