# Implementation and evaluation of the Y-Check comprehensive adolescent health check-up intervention in Zimbabwe: a pre−post mixed-methods study

**Authors:** Aoife M. Doyle, Farirai Nzvere, Salome Manyau, Victoria Simms, Ines Li Lin, Faith R. Kandiye, Chipo Ashley Nyamayaro, Michaela Takawira, Rudo M. S. Chingono, Mandikudza Tembo, Ronald Manhibi, Ethel Dauya, Chido Dziva Chikwari, Giulia Greco, Sarah Bernays, Valentina Baltag, Hannah Maisiri, Tonderai Kasu, Wenceslas Nyamayaro, Tsitsi Bandason, Constance R. S. Mackworth-Young, Prerna Banati, Helen A. Weiss, David A. Ross, Rashida A. Ferrand

PMC · DOI: 10.1038/s41591-025-04156-x · Nature Medicine · 2026-02-02

## TL;DR

A health check program for Zimbabwean adolescents was found to be feasible and effective in improving health outcomes.

## Contribution

The study provides evidence on the feasibility and impact of a comprehensive adolescent health check-up in a low-income setting.

## Key findings

- 70.8% of adolescents with health issues received appropriate care or referral.
- Improvements were observed in nutrition, quality of life, self-esteem, and educational outcomes.
- The program successfully identified untreated conditions and linked adolescents to services.

## Abstract

Routine adolescent health check-ups can support healthy development and well-being, but evidence on the feasibility, acceptability and effectiveness of contextually relevant comprehensive check-ups in low- and middle-income settings is limited. We conducted a hybrid implementation-effectiveness study incorporating a mixed-methods pre−post design of Y-Check, a comprehensive health check-up intervention in Zimbabwe, as part of a multicountry study developed and coordinated by the World Health Organization. Eligible participants were 10–19-year-old adolescents attending school or community venues. We used self-administered digital questionnaires, provider-led clinical tests and nurse reviews to screen for 25 conditions/behaviors. We provided health promotion, on-site care and referral to relevant providers. From October 2022 to September 2023, 2,097 adolescents were enrolled, of whom 1,843 (87.9%) were seen at 6 months. The primary outcome of appropriate care and/or referral(s) for all identified issues was achieved for 70.8% (95% confidence interval: 68.7–72.9%) of 1,865 participants with at least one issue. At follow-up, there were improvements in nutrition, health-related quality of life, self-esteem, behaviors and educational outcomes. The intervention was feasible and largely acceptable. Uptake of referral services varied by issue. Y-Check cost US$47 per participant. Through Y-Check, we identified untreated conditions and risk behaviors and successfully treated and linked adolescents to services. Here we provide evidence on the potential of the intervention to positively impact health and well-being.

A WHO-supported pre−post study shows that implementation of the Y-Check comprehensive health check program is feasible and acceptable for adolescents in Zimbabwe, offering screening for 25 health conditions and behaviors, health promotion, on-site care and referral.

## Full-text entities

- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

21 references — full list in the complete paper: https://tomesphere.com/paper/PMC12920085/full.md

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Source: https://tomesphere.com/paper/PMC12920085