# A Rare Adolescent Presentation of Morvan Syndrome: Diagnostic Challenges and Therapeutic Response

**Authors:** Muhammad Umar, Majeed Ullah, Umm E. Salma Shabbar Banatwala, Ayesha Afridi, Umama Alam, Okasha Tahir, Fatima Sajjad, Muhammad Abdullah Ali, F. N. U. Noormal, Jibran Ikram

PMC · DOI: 10.1002/ccr3.72122 · Clinical Case Reports · 2026-02-19

## TL;DR

A 17-year-old with Morvan syndrome showed unusual symptoms and improved with early immunotherapy.

## Contribution

Highlights atypical adolescent presentation and effective treatment of Morvan syndrome without thymoma.

## Key findings

- Severe back pain, muscle twitching, hallucinations, and hyponatremia occurred in a 17-year-old.
- Symptoms improved with corticosteroids and plasmapheresis.
- No thymoma or malignancy was present, unlike typical adult cases.

## Abstract

Morvan syndrome is a rare autoimmune disorder that predominantly affects adults, but it can also present in adolescents with atypical symptoms. This case of a 17‐year‐old patient exhibited severe back pain, muscle twitching, visual hallucinations, and hyponatremia, without the thymoma or malignancy commonly observed in adult cases. Early diagnosis and prompt immunotherapy with corticosteroids and plasmapheresis resulted in significant symptom improvement, highlighting the importance of timely intervention in complex neuroimmunological disorders.

## Linked entities

- **Diseases:** Morvan syndrome (MONDO:0008718)

## Full-text entities

- **Genes:** CNTNAP2 (contactin associated protein 2) [NCBI Gene 26047] {aka AUTS15, CASPR2, CDFE, NRXN4, PTHSL1}, LGI1 (leucine rich glioma inactivated 1) [NCBI Gene 9211] {aka ADLTE, ADPAEF, ADPEAF, DEE121, EPITEMPIN, EPT}
- **Diseases:** malignancies (MESH:D009369), lung cancer (MESH:D008175), SIADH (MESH:D007177), insomnia (MESH:D007319), Hyponatremia (MESH:D007010), Muscle stiffness (MESH:D019042), autoimmune neurological disorder (MESH:D020274), body aches (MESH:D010146), fever (MESH:D005334), seizures (MESH:D012640), autonomic (MESH:D001342), neuroimmunological disorders (MESH:D009358), Morvan Syndrome (OMIM:201300), autoimmune (MESH:D001327), dysautonomia (MESH:D054969), confusion (MESH:D003221), fatigue (MESH:D005221), testicular cancer (MESH:D013736), neuropsychiatric (MESH:C000631768), weight loss (MESH:D015431), hallucinations (MESH:D006212), back pain (MESH:D001416), encephalopathy (MESH:D001927), Isaac syndrome (MESH:D020386), amnesia (MESH:D000647), memory impairment (MESH:D008569), cognitive impairment (MESH:D003072), Limbic encephalitis (MESH:D020363), lymphoma (MESH:D008223), thymoma (MESH:D013945), peripheral nerve hyperexcitability (MESH:D010523)
- **Chemicals:** Azathioprine (MESH:D001379), vitamin D (MESH:D014807), methylprednisolone (MESH:D008775), Pregabalin (MESH:D000069583), sodium (MESH:D012964), calcium (MESH:D002118), steroids (MESH:D013256), prednisone (MESH:D011241)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Cell lines:** EU90 — Homo sapiens (Human), Ovarian adenocarcinoma, Cancer cell line (CVCL_A8KK)

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12920059/full.md

## References

12 references — full list in the complete paper: https://tomesphere.com/paper/PMC12920059/full.md

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Source: https://tomesphere.com/paper/PMC12920059