# Investigating the role of perceived autonomy support in moderating the association between diabetes stigma and psychological and diabetes self-management outcomes among adults with type 2 diabetes in Ghana

**Authors:** Samuel Akyirem, Katie Wang, Gail Melkus, Soohyun Nam, Frank Micah, Emmanuel Ekpor, LaRon E. Nelson, Ilse Bloom, Alejandro Torrado Pacheco, Julia Robinson

PMC · DOI: 10.1371/journal.pgph.0006027 · PLOS Global Public Health · 2026-02-19

## TL;DR

This study explores how feeling supported in making health decisions can reduce the negative effects of diabetes stigma on mental health and self-care in Ghana.

## Contribution

The study introduces perceived autonomy support as a novel moderator of diabetes stigma effects in a Ghanaian context.

## Key findings

- Perceived autonomy support is linked to lower anxiety and depression and better diabetes self-management.
- Higher autonomy support reduces the negative impact of diabetes stigma on self-management behaviors.
- Autonomy-supportive care is suggested as a strategy to mitigate diabetes-related stigma effects.

## Abstract

Studies on diabetes-related stigma rarely focus on identifying or examining protective factors (e.g., social support and healthcare environment) that can mitigate the adverse effect of this social phenomenon. In this cross-sectional study, we examined perceived autonomy support, a concept from the self-determination theory, as a moderator of the association between diabetes-related stigma and its adverse behavioral and psychological (depression, diabetes distress, and anxiety) correlates. We recruited 190 adults with type 2 diabetes (T2D) from a tertiary hospital in Ghana. We assessed diabetes-related stigma, depression, anxiety, diabetes distress, diabetes self-management, and perceived autonomy support using psychometric instruments. Hierarchical multivariable linear regressions were used to evaluate moderation effects of perceived autonomy support. Participants had an average age of 59.44 (standard deviation [SD] = 10.7) years, were mostly female (70.5%, n = 134), and had had T2D diagnosis for a median of 14.5 years. Autonomy support was directly associated with lower anxiety and depression and better diabetes self-management behaviors. Greater perceived autonomy support reduced the negative association between diabetes-related stigma and diabetes self-management (β = 0.20, 95% confidence interval [CI]: 0.01 to 0.39; p = 0.041). Perceived autonomy support buffered the negative effects of diabetes stigma on self-management. These findings highlight autonomy-supportive care as a promising strategy to address the adverse effects of diabetes-related stigma in Ghana.

## Linked entities

- **Diseases:** diabetes (MONDO:0005015), type 2 diabetes (MONDO:0005148), depression (MONDO:0002050), anxiety (MONDO:0005618)

## Full-text entities

- **Genes:** INS (insulin) [NCBI Gene 3630] {aka IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10}
- **Diseases:** neurological diseases (MESH:D020271), diabetes distress (MESH:D012128), Anxiety Symptoms (MESH:D001008), injuries (MESH:D014947), Diabetes (MESH:D003920), cancer (MESH:D009369), eye problems (MESH:D005134), Anxiety (MESH:D001007), T2D (MESH:D003924), Depression (MESH:D003866), dementia (MESH:D003704), HIV (MESH:D015658), cognitive decline (MESH:D003072), anemia (MESH:D000740), hypertension (MESH:D006973), death (MESH:D003643), glucose-6-phosphate dehydrogenase deficiency (MESH:D005955), hypoglycemia (MESH:D007003), end-stage kidney disease (MESH:D007676), weight loss (MESH:D015431)
- **Chemicals:** blood glucose (MESH:D001786), steroids (MESH:D013256), Glucose (MESH:D005947), PGPH-D-25-03130 (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Mutations:** A1C

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12919806/full.md

## References

61 references — full list in the complete paper: https://tomesphere.com/paper/PMC12919806/full.md

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Source: https://tomesphere.com/paper/PMC12919806