# Knowledge flows from science to AI technology: Identifying core and brokerage technological roles

**Authors:** Seokhui Lee, Jisoo Hur, Junseok Hwang, Dieter F. Kogler, Keungoui Kim

PMC · DOI: 10.1371/journal.pone.0341005 · PLOS One · 2026-02-19

## TL;DR

This paper explores how scientific knowledge influences AI technology development by analyzing patents and scientific publications from 2002 to 2021.

## Contribution

The study introduces a semantic science-technology exploration framework tailored for AI, combining patent classification and topic modeling.

## Key findings

- AI patents are categorized into four groups based on CPC co-occurrence networks.
- BERTopic modeling reveals key scientific topics influencing AI technological trends.
- The framework identifies structural pathways of science-to-technology knowledge flow in AI.

## Abstract

The rapid advancement of artificial intelligence (AI) technologies has not only driven convergence with diverse technological domains but also swiftly spread across various industrial sectors. As a knowledge-intensive field, AI is particularly shaped by the flow of knowledge from scientific research to technological development, yet remains insufficiently examined in a systematic and structural way. This study addresses this gap by investigating science-to-technology knowledge flow that underpins AI’s technological evolution. We propose a semantic science-technology exploration framework specifically designed for the AI domain, consisting of the two stages: technology classification and semantic topic exploration. First, AI patents are classified into four categories using centrality measures derived from a CPC co-occurrence network. Then, we extract abstracts from both patents and their cited scientific publications to apply BERTopic modelling and generate topic labels using generative AI. Analyzing AI-related patents filed from 2002 to 2021, we trace key technological trends and elucidate the structural pathways of knowledge flow science to technology. The findings offer practical implications for corporate R&D strategies and innovation policy design in the era of AI.

## Full-text entities

- **Genes:** F3 (coagulation factor III, tissue factor) [NCBI Gene 2152] {aka CD142, TF, TFA}
- **Diseases:** vascular abnormalities (MESH:D014652), AI (MESH:C538142), CPC (MESH:D008310), FAMILY (MESH:D000073376)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Mutations:** G06F, G08G, G16H, H04L, G06V, H04N, G06N, G06Q

## Full text

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## Figures

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## References

61 references — full list in the complete paper: https://tomesphere.com/paper/PMC12919798/full.md

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Source: https://tomesphere.com/paper/PMC12919798