# Development and validation of the Physical Capacity Score (PiC) to overcome the lack of correlation among traditional physical tests in detecting age-related decline

**Authors:** Gennaro Boccia, Paolo Riccardo Brustio, Anna Mulasso, Francesco Tufo, Alberto Rainoldi, Laurent Mourot, Laurent Mourot, Laurent Mourot

PMC · DOI: 10.1371/journal.pone.0343122 · PLOS One · 2026-02-19

## TL;DR

Researchers created a new Physical Capacity Score platform to better assess age-related physical decline using multiple tests.

## Contribution

The study introduces a validated platform combining hardware and software for automated physical test analysis.

## Key findings

- The platform showed high repeatability with COV <10% and ICC >0.90 for most tests.
- Physical capacities like cardiorespiratory fitness showed the highest age-related decline (η2 = 0.389).
- PCA revealed significant age-related differences in overall physical capacity scores (η2 = 0.301).

## Abstract

We developed the Physical Capacity Score, a set of validated and commonly used physical tests for adults, administered through a custom-built hardware and software platform that enables automated data collection and analysis. This study aimed to evaluate the platform’s repeatability, examine age-related differences, and explore the relationships between different physical capacities in a sample of adults. A total of 812 participants (aged 18–68 years, 63.5% female) were recruited. Participants completed six physical tests: finger tapping, handgrip strength, single-leg stance, sit-and-reach, five-times sit-to-stand, and the YMCA 3-minute step test. Outcome data were standardized by gender (z-scores) and analyzed across age groups using ANOVA. Pearson’s correlation coefficient (r) was used to assess redundancy among outcomes, and Principal Component Analysis (PCA) was conducted. In a test-retest analysis, all variables demonstrated coefficient of variation (COV) <10% and intraclass correlation coefficient (ICC) >0.90, except for CoP path length (COV = 10.5%, ICC = 0.64). Correlations among outcomes were weak (r range: 0.036–0.373). While all physical capacities declined with age (p < 0.001), effect sizes varied: from the least to the most age-sensitive outcome (η2 values), we found differences in handgrip strength (η2 = 0.035), sit-and-reach (η2 = 0.050), finger tapping (η2 = 0.059), CoP path length (η2 = 0.095), lower-limb power (η2 = 0.148), and cardiorespiratory fitness (η2 = 0.389). The average PCA component scores revealed large age-related differences (η2 = 0.301). Our findings suggest that the developed platform is a valuable tool for assessing physical function, and all physical tests captured distinct aspects of physical capacities. This highlights the necessity of employing a comprehensive battery of tests to gain a holistic understanding of an individual’s physical health and detect age-related decline effectively.

## Full-text entities

- **Genes:** CRH (corticotropin releasing hormone) [NCBI Gene 1392] {aka CRF, CRH1}
- **Diseases:** injuries (MESH:D014947), dyslipidemia (MESH:D050171), physical (MESH:D059445), Muscle (MESH:D019042), falls (MESH:C537863), loss of independence (MESH:D064129), fatigue (MESH:D005221), functional (MESH:D003291), Poor balance (MESH:D009123), hypertension (MESH:D006973), cardio-respiratory adverse events (MESH:D064420), reduction in (MESH:D015431), type 2 diabetes mellitus (MESH:D003924), -related (MESH:D019973)
- **Chemicals:** oxygen (MESH:D010100), cholesterol (MESH:D002784), PONE-D-25-42580R1 (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

63 references — full list in the complete paper: https://tomesphere.com/paper/PMC12919782/full.md

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Source: https://tomesphere.com/paper/PMC12919782