# Co-circulation of Plasmodium vivax and Arboviruses in the Brazil-French Guiana Border

**Authors:** Marcelo Cerilo-Filho, Estela dos Santos Medeiros, Marcelo de Lima Arouca, Marrara Pereira Sampaio, Rubens Alex de Oliveira Menezes, Margarete do Socorro Mendonça Gomes, José Rodrigo Santos Silva, Andréa Regina de Souza Baptista, Luciane Moreno Storti-Melo, Ricardo Luiz Dantas Machado

PMC · DOI: 10.1590/0037-8682-0226-2025 · Revista da Sociedade Brasileira de Medicina Tropical · 2026-02-13

## TL;DR

The study finds that malaria and arboviruses like dengue and chikungunya commonly co-occur in a tropical region, suggesting the need for combined surveillance.

## Contribution

This study provides new insights into the co-circulation of Plasmodium vivax and arboviruses in the Brazil-French Guiana border region.

## Key findings

- High IgG reactivity for dengue and chikungunya viruses was observed in the study population.
- Co-reactivity between Plasmodium vivax and arboviruses was frequent.
- Zika virus detection was minimal in the tested samples.

## Abstract

Co-circulation of Plasmodium vivax and arboviruses is a significant but underexplored public health concern in tropical regions.

We analyzed 300 serum samples collected between 2014 and 2015 from the Brazil-French Guiana border, including 102 malaria cases and 198 controls, using rapid tests for Immunoglobulin M (IgM), Immunoglobulin G (IgG), and Non-Structural Protein 1 (NS1).

High IgG reactivity for dengue and chikungunya viruses was observed. Co-reactivity was frequent. Zika virus detection was minimal.

The overlapping transmission of P. vivax and arboviruses highlights the need for integrated surveillance strategies to better address co-circulation/co-infection risks.

## Linked entities

- **Diseases:** malaria (MONDO:0005136), dengue (MONDO:0005502), chikungunya (MONDO:0017941)
- **Species:** Plasmodium vivax (taxon 5855)

## Full-text entities

- **Genes:** IVNS1ABP (influenza virus NS1A binding protein) [NCBI Gene 10625] {aka ARA3, FLARA3, HSPC068, IMD70, KLHL39, ND1}
- **Diseases:** viremia (MESH:D014766), P. vivax (MESH:D016780), dengue infection (MESH:D003715), nausea (MESH:D009325), febrile (MESH:D000071072), vomiting (MESH:D014839), febrile illnesses (MESH:D005334), headache (MESH:D006261), borne diseases (MESH:D017282), myalgia (MESH:D063806), parasites (MESH:D010272), Malaria (MESH:D008288), vector (MESH:D000079426), arboviral diseases (MESH:D004671), parasitemia (MESH:D018512), infection (MESH:D007239), chills (MESH:D023341)
- **Species:** Zika virus (no rank) [taxon 64320], Anopheles (series) [taxon 44484], Dengue virus (no rank) [taxon 12637], Plasmodium vivax (malaria parasite P. vivax, species) [taxon 5855], Chikungunya virus (no rank) [taxon 37124], Human parvovirus B19 (no rank) [taxon 10798], Aedes (subgenus) [taxon 149531], Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

15 references — full list in the complete paper: https://tomesphere.com/paper/PMC12918724/full.md

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Source: https://tomesphere.com/paper/PMC12918724