# The relationship between serum levels of miR-342 and miR-148a and acute lung injury in sepsis patients

## TL;DR

This study found that sepsis patients with acute lung injury have lower levels of miR-342 and higher levels of miR-148a, which can help predict lung injury severity.

## Contribution

The study identifies miR-342 and miR-148a as potential biomarkers for predicting acute lung injury in sepsis patients.

## Key findings

- Sepsis patients with ALI had significantly lower miR-342 and higher miR-148a levels compared to controls.
- miR-342 and miR-148a levels changed with ALI severity and correlated with clinical indicators like PaCO2 and OI.
- Combining miR-342 and miR-148a improved ALI prediction accuracy with an AUC of 0.896.

## Abstract

To investigate the relationship between serum miR-342, miR-148a, and acute lung injury (ALI) in sepsis patients.

A total of 177 sepsis patients were divided into ALI and non-ALI groups; ALI patients were further classified as mild, moderate, or severe. 162 pneumonia patients served as controls. Serum miR-342 and miR-148a levels were measured using RT-qPCR.

Sepsis patients had lower miR-342 and higher miR-148a than controls (p<0.05). Compared with non-ALI patients, the ALI group showed higher miR-148a, PaCO2, APACHE II scores, and RI, but lower miR-342 and OI (p<0.05). miR-342 decreased and miR-148a increased with ALI severity. Correlation analysis revealed that miR-342 was negatively correlated with PaCO2, APACHE II, and RI, and positively with OI, while miR-148a showed opposite trends. The AUC for predicting ALI using miR-342, miR-148a, and their combination was 0.818, 0.775, and 0.896, respectively.

Sepsis patients with ALI exhibit low serum miR-342 and high miR-148a, and their combination can effectively predict ALI occurrence.