# Observational retrospective study on neonatal umbilical cord care: OZOILE on cord separation time and other clinical complications

## TL;DR

This study shows that OZOILE, a natural formulation, can safely speed up umbilical cord separation in newborns and reduce complications.

## Contribution

The study introduces OZOILE as a novel, natural alternative for umbilical cord care with promising clinical outcomes.

## Key findings

- OZOILE application led to cord detachment in 5 to 7 days without complications.
- OZOILE reduced secondary alterations of the umbilical stump.
- The study supports OZOILE as a viable umbilical cord care option.

## Abstract

Neonatal infections, which continue to be a major cause of morbidity and mortality globally, can be avoided with proper umbilical cord care. There is still no widely recognized standard for cord care despite numerous antiseptic techniques, and the hunt for safe, natural, and efficient substitutes is becoming necessary. In this regard, OZOILE, a formulation based on stable ozonides with wound-healing and antibacterial qualities, may be a viable choice. The purpose of this study was to retrospectively assess the impact of topical OZOILE on the timing of umbilical cord detachment and the avoidance or reduction of infection-related problems in newborns.

The study was conducted in the Complex Operational Unit of Neonatology and Neonatal Intensive Care of the “Annunziata” Hospital-Cosenza (Italy) and included healthy newborns with a gestational age from the 35th to the 41st weeks of gestation, born to mothers with age ranging from 18 to 40 years.

Daily application of OZOILE spray oil, directly to the umbilical cord 3 times a day was able the stump fell off in a short time from 5 to 7 days and without any complications. OZOILE reduces secondary alterations of falling umbilical stump.

In conclusion, OZOILE intervention could be a good candidate for umbilical cord care.