# CMV Preventive and Treatment Studies in Children Undergoing Haematopoietic Stem Cell Transplant: A Systematic Review

**Authors:** Lara Fusani, Eleonora Fusco, Mariana Fonseca, Judith Breuer, Kanchan Rao, Luisa Galli, Alasdair Bamford, Seilesh Kadambari

PMC · DOI: 10.1002/rmv.70120 · Reviews in Medical Virology · 2026-02-18

## TL;DR

This paper reviews the current evidence for preventing and treating CMV in children who have undergone stem cell transplants and highlights the need for more research.

## Contribution

The study systematically reviews the limited evidence on CMV prevention and treatment in pediatric HSCT patients.

## Key findings

- Current evidence for preventing and treating CMV in children undergoing HSCT is limited.
- The review identifies gaps in knowledge that could inform future research and evidence-based management strategies.

## Abstract

Cytomegalovirus (CMV) is one of the most important infectious causes of morbidity and mortality in children undergoing haematopoietic stem cell transplant (HSCT). However, the evidence for preventing and treating CMV disease in children in this context remains limited. We sought to review the current available evidence regarding the prevention and management of CMV infection and disease in children with HSCT and propose future research areas which could better inform evidence‐based management.

## Full-text entities

- **Diseases:** anaemia (MESH:D000743), hepatitis (MESH:D056486), renal dysfunction (MESH:D007674), bacterial (MESH:D001424), Infectious Diseases (MESH:D003141), fungal infections (MESH:D009181), CMV viral reactivation (MESH:D014777), neutropenia (MESH:D009503), deaths (MESH:D003643), abnormalities (MESH:D000014), VSTs (MESH:D016399), gastrointestinal side effects (MESH:D064420), end-organ disease (MESH:C564816), endocrine (MESH:D004700), colitis (MESH:D003092), retinitis (MESH:D012173), bone marrow suppression (MESH:D001855), gastrointestinal adverse events (MESH:D002318), Infections (MESH:D007239), encephalitis (MESH:D004660), CMV pneumonia (MESH:D011014), seropositive (MESH:D006679), CMV Ig (MESH:D003586), hypogammaglobulinemia (MESH:D000361), pulmonary failure (MESH:D012131), CMV reactivation (MESH:D000085343), renal (MESH:D006030), CMV retinitis (MESH:D017726), leucopenia (MESH:C536227), renal/hepatic impairment (MESH:D008107), GVHD (MESH:D006086)
- **Chemicals:** LMV (MESH:C000588473), cyclosporine (MESH:D016572), VGCV (MESH:D000077562), CMV-Ig (-), valacyclovir (MESH:D000077483), Acyclovir (MESH:D000212), Maribavir (MESH:C400401), Foscarnet (MESH:D017245), CDV (MESH:D000077404), GCV (MESH:D015774)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

53 references — full list in the complete paper: https://tomesphere.com/paper/PMC12917297/full.md

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Source: https://tomesphere.com/paper/PMC12917297