# Computational design of foldable origami-based compressive ultrasound sensing

**Authors:** Nicolas Hochuli, Tim Wünsch, Weiye Li, Xiaohan Han, Daniel Razansky, Tino Stanković, Héctor Estrada

PMC · DOI: 10.1038/s41598-026-37215-5 · Scientific Reports · 2026-01-31

## TL;DR

Researchers designed foldable origami structures with ultrasound sensing to improve imaging with simpler electronics.

## Contribution

A novel foldable origami-based ultrasound sensing system that enhances sensitivity and enables single-pixel imaging.

## Key findings

- FOCUS achieves an average structure similarity index measure of 0.63 for synthetic target images.
- The system maintains performance under geometric distortions and electrical noise.
- Model-based reconstruction recovers 2D and 3D images from varying origami folding states.

## Abstract

Ultrasound imaging is an essential part of the modern clinical routine. However, its dependence on costly multichannel electronics limits its use in chronic monitoring of disease. Single-detector compressed-sensing approaches have been proposed to simplify the signal acquisition pipeline, but they suffer from reduced acoustic sensitivity due to reliance on multiple scattering topologies. We propose foldable origami structures with built-in ultrasound sensing capabilities for single-pixel imaging that increase the acoustic sensitivity by leveraging a foldable transducer geometry. By detecting ultrasound fields at various origami folding states, target images in two- and three-dimensions are recovered using model-based reconstruction techniques. We simulated the Foldable Origami-based Compressive Ultrasound Sensing (FOCUS) concept and inverse designed the origami geometry for maximum imaging performance. We quantified the performance of the FOCUS concept with the reconstruction accuracy of synthetic target images including point-scatterers and vessel-like structures, reaching an average structure similarity index measure of 0.63 and \documentclass[12pt]{minimal}
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				\begin{document}$$\:{L}_{2}$$\end{document} error of 11.89. We showed that the optimized FOCUS pattern remains effective even when exposed to geometric distortions and electrical noise. Our approach can tailor the FOCUS design to various targets, scales, and applications, potentially transforming ultrasound imaging devices through miniaturized single-channel electronics.

The online version contains supplementary material available at 10.1038/s41598-026-37215-5.

## Full-text entities

- **Genes:** CD46 (CD46 molecule) [NCBI Gene 4179] {aka AHUS2, MCP, MIC10, TLX, TRA2.10}
- **Chemicals:** polymers (MESH:D011108)
- **Cell lines:** Miura-ori — Homo sapiens (Human), Transformed cell line (CVCL_JE64)

## Full text

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## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12916773/full.md

## References

12 references — full list in the complete paper: https://tomesphere.com/paper/PMC12916773/full.md

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Source: https://tomesphere.com/paper/PMC12916773