# Current diagnosis, epidemiology, and management of interstitial lung abnormalities

**Authors:** Teng Moua, Misbah Baqir, Vasilios Tzilas, Jay H. Ryu

PMC · DOI: 10.3389/fmed.2026.1732754 · Frontiers in Medicine · 2026-02-05

## TL;DR

This review discusses interstitial lung abnormalities, their risk factors, and management, focusing on how they may lead to future lung disease.

## Contribution

The paper provides a narrative review of ILA definitions, epidemiology, and management strategies, highlighting current challenges and knowledge gaps.

## Key findings

- ILAs are often found in older ever-smokers during CT scans for unrelated reasons.
- There is growing interest in understanding ILA risk factors due to increasing prevalence.
- Current management and definitions of ILAs remain unclear and require further research.

## Abstract

Interstitial lung abnormalities (ILAs) are incidental nondependent radiologic findings that may portend early or future interstitial lung disease (ILD), but do not meet specific criteria at the time of presentation. They are subclinical by definition and found more commonly in older ever-smokers undergoing computed tomography (CT) imaging for other indications, including cardiac or lung cancer screening programs. As ILA prevalence increases, driven by an aging population and heightened awareness in younger patients, understanding risk factors for their development and progression has gained recent interest, particularly for optimizing subsequent ILD outcomes. This narrative review summarizes current ILA definitions, epidemiology, risk stratification, and management, while highlighting current challenges and knowledge gaps.

## Linked entities

- **Diseases:** interstitial lung disease (MONDO:0015925), lung cancer (MONDO:0005138)

## Full-text entities

- **Genes:** LEP (leptin) [NCBI Gene 3952] {aka LEPD, OB, OBS}, IL6 (interleukin 6) [NCBI Gene 3569] {aka BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2}, MUC5B (mucin 5B, oligomeric mucus/gel-forming) [NCBI Gene 727897] {aka MG1, MUC-5B, MUC5, MUC9}
- **Diseases:** infectious (MESH:D003141), emphysematous cysts (MESH:D041882), coronary calcifications (MESH:D003323), ILAs (MESH:D017563), pulmonary fibrosis (MESH:D011658), LDCT (MESH:C000719218), ATS (MESH:C000719191), sleep fragmentation (MESH:D012892), OSA (MESH:D020181), adiposity (MESH:D018205), IV (MESH:D006011), heart failure (MESH:D006333), weight loss (MESH:D015431), Insulin resistance (MESH:D007333), IPF (MESH:D054990), infection (MESH:D007239), interstitial abnormalities (MESH:D065167), deaths (MESH:D003643), Traction bronchiectasis (MESH:D001987), parenchymal abnormalities (MESH:D002543), radiologic abnormalities (MESH:D000014), stage I and II disease (MESH:D058625), NSCLC (MESH:D002289), squamous cell carcinoma (MESH:D002294), genetic abnormalities (MESH:D030342), reticular (MESH:C538361), COPD (MESH:D029424), pneumonitis (MESH:D011014), respiratory (MESH:D012131), anxiety and (MESH:D001007), lung injury (MESH:D055370), emphysema (MESH:D004646), LC (MESH:D008175), gene abnormalities (MESH:D002869), radiation pneumonitis (MESH:D017564), coronary disease (MESH:D003327), inflammation (MESH:D007249), GERD (MESH:D005764), disease (MESH:D004194), familial fibrosis (MESH:D005355)
- **Chemicals:** lead (MESH:D007854), asbestos (MESH:D001194), aluminum (MESH:D000535), ILA (-), ozone (MESH:D010126), azathioprine (MESH:D001379), carbon (MESH:D002244), mycophenolate (MESH:D009173)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12916703/full.md

## References

86 references — full list in the complete paper: https://tomesphere.com/paper/PMC12916703/full.md

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Source: https://tomesphere.com/paper/PMC12916703