# Sacituzumab tirumotecan (sac-TMT/MK-2870/SKB264): a novel antibody–drug conjugate in breast cancer

## TL;DR

Sacituzumab tirumotecan is a new antibody-drug conjugate showing promise in treating breast cancer with manageable side effects.

## Contribution

This paper reviews the clinical data and safety profile of sacituzumab tirumotecan, a novel ADC targeting TROP2 in breast cancer.

## Key findings

- Sacituzumab tirumotecan shows improved response and disease control rates in breast cancer patients.
- The drug has a manageable safety profile with common side effects like nausea and alopecia.
- No treatment-related deaths have been reported in clinical trials of sacituzumab tirumotecan.

## Abstract

The discovery of antibody-drug conjugates (ADCs) has revolutionized the therapeutic landscape of oncology patients, especially those suffering from breast cancer. Following the approval of the first ADC for solid tumors in breast cancer, numerous additional ADCs have also been launched in the therapeutic landscape of breast cancer and have become the new standard of care for all diverse subtypes. Sacituzumab tirumotecan (sac-TMT) (MK-2870/SKB264) is an innovative ADC targeting TROP2 and delivering a belotecan-derived topoisomerase I inhibitor payload. Several clinical trials of sac-TMT have demonstrated promising results including improved overall response and disease control rates as well as progression-free survival. The safety profile of sac-TMT seems easily manageable; adverse events include mainly grade 1/2 nausea and alopecia, while grade 3/4 neutropenia and leukopenia and grade 3/4 stomatitis have been also reported. However, no treatment-related deaths have been reported so far. Since sac-TMT offers an encouraging new option for diverse breast cancer populations with manageable toxicity profiles, this review aims to summarize the recent published data regarding its use in breast cancer.