# Alcohol and substance use in extreme environment temperatures exposures, neural mechanisms, coping mechanisms, substance use disorders, and increased hospital visits

**Authors:** Godfrey S. Bbosa, Haruna Muwonge

PMC · DOI: 10.3389/fnhum.2026.1677947 · Frontiers in Human Neuroscience · 2026-02-05

## TL;DR

Extreme temperatures can lead to increased alcohol and drug use as a coping mechanism, causing health issues and more hospital visits.

## Contribution

This paper reviews the link between extreme temperatures, substance use, and health outcomes, highlighting the need for targeted interventions.

## Key findings

- Extreme heat and cold can trigger mental disorders that lead to increased substance use.
- Substance abuse during extreme weather often results in hospital visits and health complications.
- Developing nations face significant challenges due to these interconnected issues.

## Abstract

Extreme environmental temperature disasters exposure pose a health challenge worldwide, including the use of alcohol and other substances, thus causing a risk of substance use disorders, and increased hospital visits. A review explored alcohol and other substance use in extreme environment temperature exposures, their mechanisms to substance use disorders and hospital visits. Relevant information used in the review was obtained through a literature search of different databases and a Google search using Boolean search with different search terms. Extreme environmental temperatures, especially in heat waves, leading to chronic stress and the development of mental disorders that trigger the use and abuse of alcohol and other drugs, especially alcohol, opioids, cocaine, cannabis, ecstasy, tobacco smoking, as coping mechanisms against heat stress–induced mental illnesses. Abuse of these substances often leads to SUD, drug intoxication, dehydration, and other health challenges often associated with increased hospital visits during the extreme weather temperatures (hot and cold). This conundrum of extreme weather, mental illnesses, and alcohol and substance use, pose significant public health challenges to the individual, communities, and society, and the already dilapidated healthcare systems, especially in developing nations. However, further studies are needed to understand the extreme weather temperatures, stress, mental illnesses, alcohol and other substances, and SUD interaction that can aid in developing intervention programs. Extreme weather temperature exposure triggers alcohol and other substance use, often leading to substance use disorders, hospital visits (hospitalization), and death, posing health a challenge to healthcare facilities, especially in developing nations.

## Linked entities

- **Chemicals:** alcohol (PubChem CID 702), opioids (PubChem CID 126961754), cocaine (PubChem CID 2826), ecstasy (PubChem CID 1615)

## Full-text entities

- **Genes:** CREB1 (cAMP responsive element binding protein 1) [NCBI Gene 1385] {aka CREB, CREB-1}, HSPB2 (heat shock protein family B (small) member 2) [NCBI Gene 3316] {aka HSP27, Hs.78846, LOH11CR1K, MKBP}, EIF2A (eukaryotic translation initiation factor 2A) [NCBI Gene 83939] {aka CDA02, EIF-2A, MST089, MSTP004, MSTP089}, HSP90AA1 (heat shock protein 90 alpha family class A member 1) [NCBI Gene 3320] {aka EL52, HEL-S-65p, HSP86, HSP89A, HSP90A, HSP90N}, TJP1 (tight junction protein 1) [NCBI Gene 7082] {aka ZO-1}, MAPK14 (mitogen-activated protein kinase 14) [NCBI Gene 1432] {aka CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2}, EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3) [NCBI Gene 9451] {aka PEK, PERK, WRS}, OCLN (occludin) [NCBI Gene 100506658] {aka BLCPMG, PPP1R115, PTORCH1}, TNF (tumor necrosis factor) [NCBI Gene 7124] {aka DIF, IMD127, TNF-alpha, TNFA, TNFSF2, TNLG1F}, DDIT3 (DNA damage inducible transcript 3) [NCBI Gene 1649] {aka AltDDIT3, C/EBPzeta, CEBPZ, CHOP, CHOP-10, CHOP10}, HSPA4 (heat shock protein family A (Hsp70) member 4) [NCBI Gene 3308] {aka APG-2, HEL-S-5a, HS24/P52, HSPH2, RY, hsp70}, HSPD1 (heat shock protein family D (Hsp60) member 1) [NCBI Gene 3329] {aka CPN60, GROEL, HLD4, HSP-60, HSP60, HSP65}, IL1B (interleukin 1 beta) [NCBI Gene 3553] {aka IL-1, IL1-BETA, IL1F2, IL1beta}, CRH (corticotropin releasing hormone) [NCBI Gene 1392] {aka CRF, CRH1}, BDNF (brain derived neurotrophic factor) [NCBI Gene 627] {aka ANON2, BULN2}, HDAC1 (histone deacetylase 1) [NCBI Gene 3065] {aka GON-10, HD1, KDAC1, RPD3, RPD3L1}, HSP90B2P (heat shock protein 90 beta family member 2, pseudogene) [NCBI Gene 7190] {aka GRP94P1, GRP94b, HSP, HSPCP2, TRA1P1, TRAP1}, CLDN5 (claudin 5) [NCBI Gene 7122] {aka AWAL, BEC1, CPETRL1, TMDVCF, TMVCF}
- **Diseases:** withdrawal (MESH:D013375), death (MESH:D003643), brain (MESH:D001927), ADHD (MESH:D001289), cardiovascular diseases (MESH:D002318), drug toxicity (MESH:D064420), dehydration (MESH:D003681), depression (MESH:D003866), drug (MESH:D000081015), sleep deprivation (MESH:D012892), neuronal death (MESH:D009410), personality disorders (MESH:D010554), dementia (MESH:D003704), drug intoxication (MESH:D000435), bipolar disorder (MESH:D001714), migraines (MESH:D008881), heat stroke (MESH:D018883), ill-health (MESH:D000071069), chronic diseases (MESH:D002908), drug overdose (MESH:D062787), cognitive deficiencies (MESH:D003072), inflammation (MESH:D007249), trauma (MESH:D014947), neurodegeneration (MESH:D019636), diseases (MESH:D004194), addictive behaviors (MESH:D000437), Parkinson's disease (MESH:D010300), respiratory diseases (MESH:D012140), opioid pain (MESH:D010146), sleep disorders (MESH:D012893), neurotic disorders (MESH:D009497), poisoning (MESH:D011041), Huntington's disease (MESH:D006816), diabetes mellitus (MESH:D003920), neurotoxicity (MESH:D020258), mental disorders (MESH:D001523), SUD (MESH:D019966), Alzheimer's (MESH:D000544), anxiety (MESH:D001007), neuroinflammation (MESH:D000090862), schizophrenia (MESH:D012559), edema (MESH:D004487), sleep disruption (MESH:D019958), TBI (MESH:D000070642), neurological diseases (MESH:D020271), mood disorders (MESH:D019964), respiratory failure (MESH:D012131), stroke (MESH:D020521), accidents (MESH:D000081084), fatigue (MESH:D005221), PTSD (MESH:D013313), hyperthermia (MESH:D005334), opioid abuse (MESH:D009293), seizures (MESH:D012640), neurological disorders (MESH:D009461), ischemia (MESH:D007511), anxiety disorders (MESH:D001008)
- **Chemicals:** bile acid (MESH:D001647), methamphetamine (MESH:D008694), heroin (MESH:D003932), ecstasy (-), caffeine (MESH:D002110), NA (MESH:D012964), benzodiazepines (MESH:D001569), suxamethonium (MESH:D013390), phencyclidine (MESH:D010622), cocaine (MESH:D003042), salicylates (MESH:D012459), nicotine (MESH:D009538), 3,4-Methylenedioxymethamphetamine (MESH:D018817), linezolid (MESH:D000069349), lithocholic acid (MESH:D008095), foxy (MESH:C042285), tapentadol (MESH:D000077432), nitrous oxide (MESH:D009609), LSD (MESH:D008238), DHEA (MESH:D003687), tramadol (MESH:D014147), amphetamines (MESH:D000662), Alcohol (MESH:D000438), morphine (MESH:D009020), DA (MESH:D004298), ROS (MESH:D017382), calcium (MESH:D002118), cannabinoids (MESH:D002186), barbiturates (MESH:D001463), psilocybin (MESH:D011562), 5-HT (MESH:D012701), flunitrazepam (MESH:D005445), nitrate (MESH:D009566), secobarbital (MESH:D012631), cortisol (MESH:D006854), pethidine (MESH:D008614), GHB (MESH:D012978), adrenaline (MESH:D004837), carbon (MESH:D002244), mescaline (MESH:D008635), codeine (MESH:D003061), diazepam (MESH:D003975), dextromethorphan (MESH:D003915), plant alkaloids (MESH:D000470), amphetamine (MESH:D000661), dinitrophenol (MESH:D004140), norepinephrine (MESH:D009638)
- **Species:** Homo sapiens (human, species) [taxon 9606], Nicotiana tabacum (American tobacco, species) [taxon 4097]

## Full text

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## References

81 references — full list in the complete paper: https://tomesphere.com/paper/PMC12916623/full.md

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Source: https://tomesphere.com/paper/PMC12916623