# Migrasome as a novel organelle: Biogenesis, physiological functions, and therapeutic potential

## TL;DR

Migrasomes are newly discovered cell structures involved in development and disease, with potential for medical use.

## Contribution

The paper introduces novel hypotheses and future directions for migrasome research and clinical applications.

## Key findings

- Migrasomes are formed during cell migration and contain signaling molecules.
- They play roles in development, angiogenesis, and disease processes.
- Potential exists for migrasomes in clinical diagnostics and therapeutics.

## Abstract

Migrasomes are a recently identified type of membranous organelle formed during cell migration. They are produced by migratory cells and widely distributed across various cells and tissues. Migrasomes contain abundant signaling and bioactive molecules, playing crucial roles in embryonic development, angiogenesis, material transport, mitochondrial quality control, and coagulation, as well as participating significantly in numerous pathological processes. This paper provides a detailed overview of the latest advancements in migrasome biology research, including migrasome biogenesis, physiological functions, isolation, and identification, and their roles in the onset, progression, diagnosis, and treatment of clinical diseases. In addition, we propose novel hypotheses and outline future research directions addressing current challenges and potential clinical applications of migrasomes, which may inform their utilization in future clinical diagnostics and therapeutics.