# "Zombie virus" like pyroptosis: Extracellular vesicles spread pyroptosis by transferring functional N-GSDMD pore

**Authors:** Yihang Zhang, Shumei Jin, Yunfen Tian, Jialong Qi

PMC · DOI: 10.1515/jtim-2026-0003 · Journal of Translational Internal Medicine · 2026-02-13

## Full-text entities

- **Genes:** GSDMD (gasdermin D) [NCBI Gene 79792] {aka DF5L, DFNA5L, FKSG10, GSDMDC1}
- **Diseases:** autoimmune (MESH:D001327), multi-organ dysfunction (MESH:D009102), GSDMD (MESH:D014808), inflammation (MESH:D007249), cytokine storm syndrome (MESH:D000080424), tissue injury (MESH:D017695), sepsis (MESH:D018805), infection (MESH:D007239), pyroEVs (MESH:C535509)
- **Chemicals:** NIG (MESH:D009550), cholesterol (MESH:D002784), LPS (MESH:D008070), lipid (MESH:D008055), Cys (MESH:D003545), GW4869 (MESH:C468773), PyroEV (-), disulfiram (MESH:D004221), DOX (MESH:D004317), phosphatidylserine (MESH:D010718)
- **Species:** Escherichia coli (E. coli, species) [taxon 562], Mus musculus (house mouse, species) [taxon 10090]

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## References

17 references — full list in the complete paper: https://tomesphere.com/paper/PMC12916272/full.md

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Source: https://tomesphere.com/paper/PMC12916272