# Ruptured Ovarian Endometrioma During Pregnancy: A Case Report and Review Highlighting Clinically Occult Risk Factors

**Authors:** Yumiko Miyazaki, Sakurako Takada, Rena Yamazaki, Shinya Hirabuki, Hiromasa Sasaki

PMC · DOI: 10.7759/cureus.101871 · Cureus · 2026-01-19

## TL;DR

This case report and review explore ovarian endometrioma rupture during pregnancy, focusing on risk factors like cyst size and adhesions.

## Contribution

The study highlights clinically occult risk factors, such as intra-abdominal adhesions, in endometrioma rupture during pregnancy.

## Key findings

- 78.5% of cases involved cysts ≥6 cm, indicating large size as a major risk factor.
- 50% of ruptures occurred in the third trimester, with all cases ≥32 weeks delivered via cesarean.
- Intra-abdominal adhesions were reported in seven cases, suggesting a possible occult risk.

## Abstract

The rupture of an ovarian endometrioma during pregnancy is a rare cause of acute abdominal pain, and its underlying risk factors are incompletely understood. We report a case of ovarian endometrioma rupture during pregnancy complicated by dense intra-abdominal adhesions and review previously reported cases to clarify potential risk factors. Twenty cases, including our case, were analyzed. Among cases with available data, 78.5% involved cysts measuring ≥6 cm, consistent with previous reports identifying large cyst size as a major risk factor. Adhesions were reported in seven cases, although most studies did not explicitly comment on their presence or absence. Regarding gestational age, 50% of cases occurred during the third trimester, and all cases presenting at ≥32 weeks of gestation were delivered by cesarean section. Beyond visible risk factors, such as cyst size and gestational age, clinically occult factors, including intra-abdominal adhesions, may also contribute to rupture risk. Careful early assessment and documentation of ovarian endometriomas may support clinical decision-making; however, the preventive role of pre-pregnancy surgical intervention warrants further investigation.

## Full-text entities

- **Genes:** GPT (glutamic--pyruvic transaminase) [NCBI Gene 2875] {aka AAT1, ALT, ALT1, GPT1, SGPT}, CMPK1 (cytidine/uridine monophosphate kinase 1) [NCBI Gene 51727] {aka CK, CMK, CMPK, UMK, UMP-CMPK, UMPK}, INPP5D (inositol polyphosphate-5-phosphatase D) [NCBI Gene 3635] {aka SHIP, SHIP-1, SHIP1, SIP-145, hp51CN, p150Ship}, SLC17A5 (solute carrier family 17 member 5) [NCBI Gene 26503] {aka AST, ISSD, NSD, SD, SIALIN, SIASD}, CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}
- **Diseases:** Cyst (MESH:D003560), acute abdomen (MESH:D000006), Ovarian Endometrioma (MESH:D010049), tenderness (MESH:D063806), bleeding (MESH:D006470), irregular uterine (MESH:D008599), blood loss (MESH:D016063), vascular disruption (MESH:D019958), abdominal pain (MESH:D015746), rupture of membranes (MESH:D005322), tumor (MESH:D009369), cyst rupture (MESH:D012421), endometrioma (MESH:D004715), Adhesions (MESH:D000267), pain (MESH:D010146), hematoma (MESH:D006406), adnexal torsion (MESH:D000082843), SHiP. (MESH:D006465), fibrosis (MESH:D005355), appendicitis (MESH:D001064), inflammatory (MESH:D007249), Hemorrhagic ascites (MESH:D001201), anemia (MESH:D000740), hypovolemic shock (MESH:D012769)
- **Chemicals:** creatinine (MESH:D003404), pentazocine (MESH:D010423), bilirubin (MESH:D001663), acetaminophen (MESH:D000082), oxygen (MESH:D010100), Cre (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12916156/full.md

## References

20 references — full list in the complete paper: https://tomesphere.com/paper/PMC12916156/full.md

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Source: https://tomesphere.com/paper/PMC12916156