# The effects of pulsed electromagnetic field therapy on pain and physical functions in patients with soft tissue injuries: a systematic review of randomised controlled trials

**Authors:** Cheryl Shu Ming Chia, Sai-Chuen Fu, Violet Man-Chi Ko, Josephine Wing Hei Lai, Meng Zhou, Patrick Shu-Hang Yung, Samuel Ka-Kin Ling

PMC · DOI: 10.3389/fspor.2026.1694944 · Frontiers in Sports and Active Living · 2026-02-05

## TL;DR

This review examines whether pulsed electromagnetic field therapy helps reduce pain and improve physical function in people with foot and ankle soft tissue injuries.

## Contribution

The study provides a systematic review of RCTs to assess the efficacy of PEMF therapy for foot and ankle soft tissue injuries.

## Key findings

- PEMF therapy significantly reduced pain in three out of four trials.
- Only one trial showed significant improvement in physical function with PEMF therapy.
- No serious adverse events were reported, only minor skin redness.

## Abstract

Foot and ankle diseases are highly prevalent in both the general and athletic populations, frequently resulting in pain, impaired physical function, and a decreased quality of life. Pulsed Electromagnetic Field (PEMF) therapy has shown beneficial effects on pain by reducing inflammation and improving circulation, yet its efficacy in treating foot and ankle soft-tissue pathologies remains unclear. This systematic review aimed to evaluate the impact of PEMF therapy on pain and physical function among individuals with foot and ankle soft-tissue pathologies.

A systematic literature search was conducted across Medline, Embase, Emcare (Ovid Nursing & Allied Health), Allied and Complementary Medicine Database (AMED), and Web of Science from database inception to May 15, 2025. Additional searches were performed using Google Scholar and clinical trial registries. Two reviewers independently screened studies and extracted data on pain and physical function outcomes.

Four randomised controlled trials (RCTs), comprising a total of 243 participants with a mean age of 48.79 years, were included in the review. In three of the four trials, PEMF therapy was administered alongside another conservative intervention, such as shockwave therapy, heel pads, or eccentric exercise, and compared to the conservative treatment alone. Only one study investigated the isolated effects of PEMF therapy vs. sham stimulation. Among the included studies, three reported statistically significant reductions in pain in the intervention groups compared to controls (p < 0.05). However, only one of three studies demonstrated a significant improvement in physical function following PEMF therapy (p < 0.05). Large heterogeneity in terms of treatment protocols and intervention parameters was observed across the studies which may limit the comparability of outcomes. No serious adverse events were reported; only minor skin redness was documented as a side effect.

PEMF therapy appears safe and effective for reducing pain in individuals with various foot and ankle soft-tissue pathologies. However, the findings on the PEMF therapy in improving physical function remain inconclusive. Future research should focus on a large-scale, standardised setting, including the PEMF therapy protocol, to evaluate the efficacy of PEMF therapy on both pain and functional outcomes in this specific population.

https://www.crd.york.ac.uk/PROSPERO/view/CRD420251076499, PROSPERO CRD420251076499.

## Full-text entities

- **Genes:** IL6 (interleukin 6) [NCBI Gene 3569] {aka BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2}, CALM1 (calmodulin 1) [NCBI Gene 801] {aka CALML2, CAM2, CAM3, CAMB, CAMC, CAMI}, CXCL8 (C-X-C motif chemokine ligand 8) [NCBI Gene 3576] {aka GCP-1, GCP1, IL8, LECT, LUCT, LYNAP}, IL1B (interleukin 1 beta) [NCBI Gene 3553] {aka IL-1, IL1-BETA, IL1F2, IL1beta}, IGF1 (insulin like growth factor 1) [NCBI Gene 3479] {aka IGF, IGF-I, IGFI, MGF}, IL10 (interleukin 10) [NCBI Gene 3586] {aka CSIF, GVHDS, IL-10, IL10A, TGIF}, TNF (tumor necrosis factor) [NCBI Gene 7124] {aka DIF, IMD127, TNF-alpha, TNFA, TNFSF2, TNLG1F}
- **Diseases:** dislocations (MESH:D004204), instability (MESH:D043171), Soft-tissue injuries of the foot and ankle (MESH:D017695), Foot and ankle diseases (MESH:D005534), plantar fasciitis (MESH:D036981), musculoskeletal complaints (MESH:D009140), rotator cuff tendinopathy (MESH:D000070636), reduced muscle strength (MESH:D009135), oedema (MESH:C536897), gastrointestinal complications (MESH:D005767), knee osteoarthritis (MESH:D020370), joint dysfunction (MESH:D007592), osteochondral defects (MESH:D010007), stiffness (MESH:C566112), Achilles Tendon disease (MESH:D052256), ligament/tendon injury (MESH:D013708), osteoarthritis (MESH:D010003), lower back pain (MESH:D017116), bone non-unions (MESH:D017759), Ankle (MESH:D016512), shoulder impingement syndrome (MESH:D019534), function decline (MESH:D060825), decreased range of motion (MESH:D009041), bone marrow oedema (MESH:D004487), bursitis (MESH:D002062), injuries (MESH:D014947), muscle wasting (MESH:D009133), inflammation (MESH:D007249), impaired physical function (MESH:D059445), Pain (MESH:D010146), fractures (MESH:D050723), skin redness (MESH:D012871)
- **Chemicals:** calcium (MESH:D002118), Ca2 + (-), nitric oxide (MESH:D009569), oxygen (MESH:D010100)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12916110/full.md

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12916110/full.md

## References

105 references — full list in the complete paper: https://tomesphere.com/paper/PMC12916110/full.md

---
Source: https://tomesphere.com/paper/PMC12916110