# Advanced gastroesophageal junction adenocarcinoma with skin involvement: a multidisciplinary perspective

## TL;DR

This paper presents a rare case of advanced stomach cancer spreading to the skin, highlighting the challenges in treating such aggressive cancer.

## Contribution

The novelty lies in reporting a rare case of gastroesophageal junction adenocarcinoma with skin metastases and its clinical management challenges.

## Key findings

- Skin metastases from GEJ adenocarcinoma are rare and indicate aggressive disease.
- Standard chemotherapy regimens failed to control progression in this case.
- Multidisciplinary care and novel strategies are needed for such cases.

## Abstract

Skin metastasis secondary to visceral malignancy is a rare but poor prognostic occurrence. We report a rare case of gastroesophageal junction (GEJ) adenocarcinoma with skin metastases, highlighting the challenges in managing such cases.

A 63-year-old male diagnosed with stage IV Siewert 3 GEJ adenocarcinoma with initial extensive skin metastases. Palliative radiation and four cycles of first-line FOLFOX resulted in progression and new skin lesions. A second-line FOLFIRI and third-lines taxane regimens failed to yield clinical improvement and stop progression. His disease worsened with widespread metastases including omentum and peritoneum. He died 9 months after initial presentation due to intestinal perforation secondary to neutropenic fever.

Skin metastases from GEJ adenocarcinoma are associated with aggressive disease chemotherapy resistance. A multidisciplinary approach, palliative care, and novel strategies are essential for managing such cases.

Graphical Abstract