# Aquagenic palmar keratoderma associated with palmoplantar hyperhidrosis: a case report

## TL;DR

A 31-year-old woman with a rare skin condition causing pain and thickening on her palms when exposed to water is reported, along with treatment attempts.

## Contribution

This case report highlights aquagenic palmar keratoderma associated with hyperhidrosis and treatment with 16% aluminum chloride.

## Key findings

- The patient experienced rapid wrinkling and hyperkeratosis upon water contact.
- Treatment with 16% aluminum chloride was evaluated but remains challenging.
- The condition was not linked to cystic fibrosis in this case.

## Abstract

Aquagenic palmoplantar keratoderma is a rare dermatological condition characterized by mild palmar thickening and burning pain upon exposure to water. A 31-year-old female with aquagenic keratoderma of the palms associated with palmoplantar hyperhidrosis presenting with wrinkling and hyperkeratosis within minutes of hand contact with water, resolving quickly after drying. While cystic fibrosis is a known association, most cases remain idiopathic. Treatment options such as 20% aluminum hydroxide, aluminum chloride (15%–20%), urea, salicylic acid, and botulinum toxin can be challenging, with the patient being evaluated after treatment with 16% aluminum chloride.