# Normative Data for Learning and Memory Test (TAMV-I) in Latin American and Spanish Children: An item response theory and linear mixed models approach

**Authors:** Eliana María Fuentes Mendoza, Laiene Olabarrieta-Landa, Alberto Rodríguez-Lorenzana, Guido Mascialino, Esperanza Vergara-Moragues, Carlos José de los Reyes-Aragón, Natalia Albaladejo-Blázquez, Natalia Cadavid-Ruiz, María José Irias Escher, Juan Carlos Arango-Lasprilla, Erick Orozco-Acosta, Diego Rivera, Alejandro Botero Carvajal, Alejandro Botero Carvajal, Alejandro Botero Carvajal

PMC · DOI: 10.1371/journal.pone.0341237 · PLOS One · 2026-02-18

## TL;DR

This study creates more accurate norms for a learning and memory test used in Spanish-speaking children by combining advanced statistical methods.

## Contribution

The study introduces a novel approach combining item response theory and linear mixed models to generate covariate-adjusted norms for the TAMV-I test.

## Key findings

- The 2PL model outperformed the Rasch model in estimating item parameters for the TAMV-I.
- Significant interactions were found for MPE*Country, Age*Trial, Sex*Country, and Trial*Country in the LMM analysis.
- The integration of IRT and LMM improved the precision and clinical validity of TAMV-I norms for diverse Spanish-speaking populations.

## Abstract

Robust normative data for pediatric learning and memory tests in Spanish-speaking populations are scarce, and existing approaches often rely on univariate methods that overlook item-level properties and inter-trial dependencies. The aim was to evaluate the item parameters of the TAMV-I using Item Response Theory (IRT) and to generate covariate-adjusted normative data through Linear Mixed Models (LMM). We hypothesized that the 2-parameter logistic (2PL) model would outperform the Rasch model and that demographic and contextual factors would show significant interactions influencing test performance. The sample consists of 1640 participants from Spain, Honduras, Ecuador, and Colombia. The inclusion criteria were being 6–17 years old, IQ ≥ 80 on TONI-2, and score<19 on the Children’s Depression Inventory (CDI). Children with a history of neurological and/or psychiatric disorders were excluded. Item parameters were determined using the 1,2-PL model. LMM were used to evaluate the effect of sociodemographic variables (sex, age, age², mean parent years of education-MPE, country, and interactions). Norms were generated based on participant ability. As a result, the item parameters were calculated and the LMM showed significant interactions for MPE*Country, Age*Trial, Sex*Country and Trial*Country. By integrating IRT with LMM, this study provides cross-national, covariate-adjusted norms for the TAMV-I, enhancing precision and clinical validity compared to previous approaches.

## Full-text entities

- **Diseases:** attention deficit hyperactivity disorder (MESH:D001289), written expression disorder (MESH:D001039), brain injury (MESH:D001930), intellectual disabilities (MESH:D008607), death (MESH:D003643), hypothyroidism (MESH:D007037), epilepsy (MESH:D004827), memory impairments (MESH:D008569), cognitive difficulties (MESH:D003072), neurodevelopmental disorders (MESH:D002658), multiple sclerosis (MESH:D009103), Infectious and Zoonotic Diseases (MESH:D015047), bipolar disorder (MESH:D001714), Depression (MESH:D003866), central nervous system disorders (MESH:D002493), sensory deficits (MESH:D012678), diabetes (MESH:D003920), neurological and/or psychiatric disorders (MESH:D001523), Alcohol Use Disorders (MESH:D000437), autism spectrum disorders (MESH:D000067877), hypoxia (MESH:D000860), systemic diseases (MESH:D034721), dyscalculia (MESH:D060705), seizures (MESH:D012640), LMMs (MESH:D004195), fatigue (MESH:D005221), learning and memory difficulties (MESH:D007859)
- **Chemicals:** cocaine (MESH:D003042), methamphetamines (MESH:D008694), PONE-D-25-02804R1 (-), heroin (MESH:D003932), barbiturates (MESH:D001463), amphetamines (MESH:D000662)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

74 references — full list in the complete paper: https://tomesphere.com/paper/PMC12915919/full.md

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Source: https://tomesphere.com/paper/PMC12915919