# Association between delivery hospitalization blood pressure and severity of postpartum admissions for hypertension

**Authors:** Mindy Pike, Judy Han, Leah Chen, Catherine M. Albright, Raj Shree

PMC · DOI: 10.1371/journal.pone.0342836 · PLOS One · 2026-02-18

## TL;DR

This study found that high blood pressure at hospital discharge after childbirth is linked to earlier postpartum hypertension admissions but not to their severity.

## Contribution

The study is the first to show a link between discharge blood pressure and timing of postpartum hypertension admissions.

## Key findings

- Blood pressure at discharge was not associated with severity of postpartum hypertension admissions.
- Elevated discharge blood pressure was linked to earlier postpartum hypertension admissions.
- 27% of cases involved new-onset hypertension after childbirth.

## Abstract

Hypertension is a leading cause of postpartum admission (PPA), but whether blood pressure (BP) at discharge from delivery hospitalization is associated with PPA severity is unknown. Furthermore, detailed characterization of presentation, management, and progression of hypertensive disorders of pregnancy (HDP) during PPA is lacking.

Retrospective study of PPAs for hypertension from 2016–2021. Exposure was highest BP within 24 hours of discharge from delivery hospitalization, classified as normal (<140/90 mmHg) or elevated (≥140/90 mmHg). The primary outcome was disease severity, measured by an aggregate “Severity Score” based on severe criteria for HDP. PPAs were further characterized by symptoms, interventions, and HDP progression. We also calculated the proportion of de novo postpartum HDP.

Among 132 patients with PPA for hypertension, 76 had normal BP and 56 had elevated BP at discharge. Severity did not differ between groups. Median time to PPA was 5 days (IQR: 3–8) and 3 days (IQR: 1–5) for the normal and elevated BP groups, respectively (β –1.59, 95% CI –3.06, –0.12). Headache was the most frequent presenting symptom. HDP diagnosis worsened in 49% of cases. 27% experienced de novo postpartum HDP.

BP at discharge was not associated with PPA severity but was linked to earlier presentation. Close to half had worsening of HDP, while de novo hypertension accounted for over a quarter of PPAs. This underscores the need for earlier identification of postpartum hypertensive complications and determination of optimal BP targets. New onset hypertension represents a substantial proportion of PPAs, representing necessary admissions, rather than re-admissions.

## Full-text entities

- **Genes:** SLC17A5 (solute carrier family 17 member 5) [NCBI Gene 26503] {aka AST, ISSD, NSD, SD, SIALIN, SIASD}
- **Diseases:** CHTN (MESH:D006973), GHTN (MESH:D046110), COVID-19 (MESH:D000086382), eclampsia (MESH:D004461), HELLP (MESH:D017359), PPA (MESH:D006473), cardiac dysfunction (MESH:D006331), PRES (MESH:D054038), pregnancy (MESH:D011254), Headache (MESH:D006261), diabetes (MESH:D003920), postpartum pulmonary edema (MESH:D011654), Preeclampsia (MESH:D011225), left ventricular dysfunction (MESH:D018487), stroke (MESH:D020521)
- **Chemicals:** PPA (-), furosemide (MESH:D005665), hydralazine (MESH:D006830), labetalol (MESH:D007741), creatinine (MESH:D003404), nifedipine (MESH:D009543), enalapril (MESH:D004656)
- **Species:** Homo sapiens (human, species) [taxon 9606], Avihepevirus magniiecur (species) [taxon 1678144]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12915911/full.md

## References

23 references — full list in the complete paper: https://tomesphere.com/paper/PMC12915911/full.md

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Source: https://tomesphere.com/paper/PMC12915911