# Analysis with LC-OCT imaging in split face with CO2 laser and 1540 nm. A case report

**Authors:** Francesco Moro, Irene Fusco, Francesca Madeddu, Luca Ambrosio, Camilla Chello, Giovanni Di Lella, Tiziano Zingoni, Laura Colonna

PMC · DOI: 10.1093/omcr/omaf296 · Oxford Medical Case Reports · 2026-02-18

## TL;DR

This case report uses LC-OCT imaging to compare the effects of CO2 laser and a combined CO2 and 1540 nm laser treatment on skin recovery.

## Contribution

The study introduces split-face LC-OCT evaluation to compare ablative and non-ablative laser treatments in real-time.

## Key findings

- Both CO2-only and CO2+1540 nm treatments showed comparable early inflammatory changes.
- The CO2+1540 nm side showed faster re-epithelialization at 7 days.
- Clinical recovery was substantial in both treatment groups.

## Abstract

The aims of this case report study was to investigate the effect of both ablative and non-ablative laser sources in the restoration of the epidermal profile with split-face confocal optical coherence tomography (LC-OCT) evaluation.

A patient was treated with a standard laser treatment that use simultaneously both ablative and non-ablative sources in split face mode; one side with CO2 alone and the other with the combined use of CO2 and a 1540 nm emission. LC-OCT imaging was carried out before the procedure (T0), at 24 hours (T1), and at 7 days (T7).

In the CO2 + 1540 nm modality, the general appearance was comparable to the CO₂-only side. At T7, the CO2-only side demonstrated substantial clinical recovery, while the combined CO2 + 1540 nm side shows faster re-epithelialization. This split-face LC-OCT evaluation highlights that both treatment modalities induce comparable early inflammatory changes.

## Full-text entities

- **Diseases:** inflammatory (MESH:D007249)
- **Chemicals:** FM (MESH:D005286), CO2 (MESH:D002245), MTZ (-), OCT (MESH:C051883)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12915051/full.md

## References

6 references — full list in the complete paper: https://tomesphere.com/paper/PMC12915051/full.md

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Source: https://tomesphere.com/paper/PMC12915051